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Research article - Peer-reviewed, 2020

The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism

Kim, Kwondo; Kwon, Taehyung; Dessie, Tadelle; Yoo, DongAhn; Mwai, Okeyo Ally; Jang, Jisung; Sung, Samsun; Lee, SaetByeol; Salim, Bashir; Jung, Jaehoon; Jeong, Heesu; Tarekegn, Getinet Mekuriaw; Tijjani, Abdulfatai; Lim, Dajeong; Cho, Seoae; Oh, Sung Jong; Lee, Hak-Kyo; Kim, Jaemin; Jeong, Choongwon; Kemp, Stephen;
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Abstract

Whole-genome sequence analysis of 172 indigenous African cattle from 16 breeds identifies 16 loci linked to environmental adaptations among crossbred animals, including a highly divergent locus in African taurine cattle putatively linked to trypanotolerance.Cattle pastoralism plays a central role in human livelihood in Africa. However, the genetic history of its success remains unknown. Here, through whole-genome sequence analysis of 172 indigenous African cattle from 16 breeds representative of the main cattle groups, we identify a major taurine x indicine cattle admixture event dated to circa 750-1,050 yr ago, which has shaped the genome of today's cattle in the Horn of Africa. We identify 16 loci linked to African environmental adaptations across crossbred animals showing an excess of taurine or indicine ancestry. These include immune-, heat-tolerance- and reproduction-related genes. Moreover, we identify one highly divergent locus in African taurine cattle, which is putatively linked to trypanotolerance and present in crossbred cattle living in trypanosomosis-infested areas. Our findings indicate that a combination of past taurine and recent indicine admixture-derived genetic resources is at the root of the present success of African pastoralism.

Published in

Nature Genetics
2020, volume: 52, number: 10, pages: 1099-1110
Publisher: NATURE RESEARCH

Authors' information

Kim, Kwondo
Seoul National University (SNU)
Kwon, Taehyung
Seoul National University (SNU)
Dessie, Tadelle
International Livestock Research Institute (ILRI)
Yoo, DongAhn
Seoul National University (SNU)
Mwai, Okeyo Ally
International Livestock Research Institute (ILRI)
Jang, Jisung
Seoul National University (SNU)
Sung, Samsun
C&K Genomics
Lee, SaetByeol
C&K Genomics
Salim, Bashir
University of Khartoum
Jung, Jaehoon
Seoul National University (SNU)
Jeong, Heesu
Seoul National University (SNU)
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Bahir Dar University
Tijjani, Abdulfatai
University of Edinburgh
Lim, Dajeong
Rural Development Administration (RDA)
Cho, Seoae
C&K Genomics
Oh, Sung Jong
Jeonbuk National University
Lee, Hak-Kyo
Jeonbuk National University
Kim, Jaemin
Gyeongsang National University
Jeong, Choongwon
Seoul National University (SNU)
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UKÄ Subject classification

Genetics and Breeding

Publication Identifiers

DOI: https://doi.org/10.1038/s41588-020-0694-2

URI (permanent link to this page)

https://res.slu.se/id/publ/108183