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Research article - Peer-reviewed, 2020

Prevalence and severity of cardiac abnormalities and arteriosclerosis in farmed rainbow trout (Oncorhynchus mykiss)

Brijs, J.; Hjelmstedt, P.; Berg, C.; Johansen, I. B.; Sundh, H.; Roques, J. A. C.; Ekstrom, A.; Sandblom, E.; Sundell, K.; Olsson, C.; Axelsson, M.; Grans, A.;

Abstract

Cardiovascular disease may pose a major threat to the health and welfare of farmed fish. By investigating a range of established cardiovascular disease indicators, we aimed to determine the prevalence, severity and consequences of this affliction in farmed rainbow trout (Oncorhynchus mykiss) from an open cage farm in the Baltic Sea, an open cage farm in a freshwater lake, and a land-based recirculating aquaculture system. We also aimed to identify environmental, anthropogenic and physiological factors contributing towards the development of the disease. The majority of trout possessed enlarged hearts with rounded ventricles (mean height:width ratios of 1.0-1.1 c.f. similar to 1.3 in wild fish) and a high degree of vessel misalignment (mean angles between the longitudinal ventricular axis and the axis of the bulbus arteriosus of 28-31 degrees c.f. similar to 23 degrees in wild fish). The prevalence and severity of coronary arteriosclerosis was also high, as 92-100% of fish from the different aquaculture facilities exhibited coronary lesions. Mean lesion incidence and severity indices were 67-95% and 3.1-3.9, respectively, which resulted in mean coronary arterial blockages of 19-32%. To evaluate the functional significance of these findings, we modelled the effects of arterial blockages on coronary blood flow and experimentally tested the effects of coronary occlusion in a sub-sample of fish. The observed coronary blockages were estimated to reduce coronary blood flow by 34-54% while experimental coronary occlusion adversely affected the electrocardiogram of trout. Across a range of environmental (water current, predation), anthropogenic (boat traffic intensity, hatchery of origin, brand of feed pellets) and physiological factors (condition factor, haematological and plasma indices), the hatchery of origin was the main factor contributing towards the observed variation in the development of cardiovascular disease. Therefore, further research on the effects of selective breeding programs and rearing strategies on the development of cardiovascular disease is needed to improve the welfare and health of farmed fish.

Keywords

Arteriosclerosis; Coronary artery; ECG; Heart morphology; Stress physiology

Published in

Aquaculture

2020, volume: 526, article number: 735417
Publisher: ELSEVIER

Authors' information

Brijs, Jeroen
Swedish University of Agricultural Sciences, Department of Animal Environment and Health
Swedish University of Agricultural Sciences, Department of Animal Environment and Health
Hjelmstedt, P.
University of Gothenburg
Swedish University of Agricultural Sciences, Department of Animal Environment and Health
Johansen, I. B.
Norwegian University of Life Sciences
Sundh, H.
University of Gothenburg
Roques, J. A. C.
University of Gothenburg
Ekstrom, A.
University of Gothenburg
Sandblom, E.
University of Gothenburg
Sundell, K.
University of Gothenburg
Olsson, C.
University of Gothenburg
Axelsson, M.
University of Gothenburg
Swedish University of Agricultural Sciences, Department of Animal Environment and Health
University of Gothenburg

UKÄ Subject classification

Fish and Aquacultural Science

Publication Identifiers

DOI: https://doi.org/10.1016/j.aquaculture.2020.735417

URI (permanent link to this page)

https://res.slu.se/id/publ/108398