Research article - Peer-reviewed, 2022
Tetramic acid based alkaloids from Aspergillus amoenus Roberg strain UP197-antibiotic properties and new pyranterreones
Nord, Christina; Levenfors, Jolanta J.; Bjerketorp, Joakim; Guss, Bengt; Oberg, Bo; Broberg, AndersAbstract
The fungus Aspergillus amoenus Roberg strain UP197 was shown to produce antibacterial tetramic acid based alkaloids. Two new compounds, pyranterreone I and J (1 and 2), were isolated and characterized, in addition to the known compounds cordylactam, 7-hydroxycordylactam, pyranterreone C, D, F and G. Neither the pyranterreones nor the cordylacctams had previously been tested for antimicrobial activity. Thus, all isolated compounds were tested against a panel of clinically important bacteria and fungi. Pyranterreone C was active against Gram-positive and Gram-negative bacteria, with minimal inhibitory concentrations (MIC) between 1 and 8 mu g/mL, whereas the MICs for all other compounds were >32 mu g/mL. Pyranoterreone C was cytotoxic towards HepG2 cells, and since pyranterreone C reacted rapidly with the nucleophile cysteine, it is likely that the observed antibacterial activity is due to the chemical reactivity rather than enzymatic affinity, making it unsuitable for development as an antibacterial drug.Keywords
Aspergillus amoenus; alkaloids; pyranterreone; antibacterial; cytotoxicPublished in
Natural Product Research2022, volume: 36, number: 4, pages: 967-973
Publisher: TAYLOR AND FRANCIS LTD
Authors' information
Nord, Christina
Swedish University of Agricultural Sciences, Department of Molecular Sciences
Swedish University of Agricultural Sciences, Department of Molecular Sciences
Swedish University of Agricultural Sciences, Department of Molecular Sciences
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Öberg, Bo
Ultupharma
Broberg, Henrik
Swedish University of Agricultural Sciences, Department of Molecular Sciences
UKÄ Subject classification
Medicinal Chemistry
Publication Identifiers
DOI: https://doi.org/10.1080/14786419.2020.1855643
URI (permanent link to this page)
https://res.slu.se/id/publ/110481