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Research article - Peer-reviewed, 2021

Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle

Hill, Sharon Rose; Taparia, Tanvi; Ignell, Rickard

Abstract

BackgroundIn the light of dengue being the fastest growing transmissible disease, there is a dire need to identify the mechanisms regulating the behaviour of the main vector Aedes aegypti. Disease transmission requires the female mosquito to acquire the pathogen from a blood meal during one gonotrophic cycle, and to pass it on in the next, and the capacity of the vector to maintain the disease relies on a sustained mosquito population.ResultsUsing a comprehensive transcriptomic approach, we provide insight into the regulation of the odour-mediated host- and oviposition-seeking behaviours throughout the first gonotrophic cycle. We provide clear evidence that the age and state of the female affects antennal transcription differentially. Notably, the temporal- and state-dependent patterns of differential transcript abundance of chemosensory and neuromodulatory genes extends across families, and appears to be linked to concerted differential modulation by subsets of transcription factors.ConclusionsBy identifying these regulatory pathways, we provide a substrate for future studies targeting subsets of genes across disparate families involved in generating key vector behaviours, with the goal to develop novel vector control tools.

Keywords

Mosquito; Olfaction; Ontogeny; Chemosensory-related genes; Neuromodulatory genes; Transcription factors

Published in

BMC Genomics
2021, volume: 22, number: 1, article number: 71
Publisher: BMC

Authors' information

Swedish University of Agricultural Sciences, Department of Plant Protection Biology
Taparia, Tanvi
Wageningen University and Research
Taparia, Tanvi
Swedish University of Agricultural Sciences, Department of Plant Protection Biology
Swedish University of Agricultural Sciences, Department of Plant Protection Biology

UKÄ Subject classification

Genetics

Publication Identifiers

DOI: https://doi.org/10.1186/s12864-020-07336-w

URI (permanent link to this page)

https://res.slu.se/id/publ/110777