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Research article - Peer-reviewed, 2021

Dogs as Sentinels for Flavivirus Exposure in Urban, Peri-Urban and Rural Hanoi, Vietnam

Pham-Thanh, Long; Nguyen-Tien, Thang; Magnusson, Ulf; Bui-Nghia, Vuong; Bui-Ngoc, Anh; Le-Thanh, Duy; Lundkvist, Ake; Can-Xuan, Minh; Nguyen-Thi Thu, Thuy; Vu-Thi Bich, Hau; Lee, Hu Suk; Nguyen-Viet, Hung; Lindahl, Johanna

Abstract

Diseases caused by flaviviruses, including dengue fever and Japanese encephalitis, are major health problems in Vietnam. This cross-sectional study explored the feasibility of domestic dogs as sentinels to better understand risks of mosquito-borne diseases in Hanoi city. A total of 475 dogs serum samples from 221 households in six districts of Hanoi were analyzed by a competitive enzyme-linked immunosorbent assay (cELISA) for antibodies to the pr-E protein of West Nile virus and other flaviviruses due to cross-reactivity. The overall flavivirus seroprevalence in the dog population was 70.7% (95% CI = 66.4-74.8%). At the animal level, significant associations between seropositive dogs and district location, age, breed and keeping practice were determined. At the household level, the major risk factors were rural and peri-urban locations, presence of pigs, coil burning and households without mosquito-borne disease experience (p < 0.05). Mosquito control by using larvicides or electric traps could lower seropositivity, but other measures did not contribute to significant risk mitigation of flavivirus exposure in dogs. These results will support better control of mosquito-borne diseases in Hanoi, and they indicate that dogs can be used as sentinels for flavivirus exposure.

Keywords

dogs; mosquito-borne flavivirus; seroprevalence; Hanoi; Vietnam

Published in

Viruses
2021, volume: 13, number: 3, article number: 507
Publisher: MDPI

Authors' information

Pham-Thanh, Long
International Livestock Research Institute (ILRI)
Pham-Thanh, Long
Uppsala University
Nguyen-Tien, Thang
International Livestock Research Institute (ILRI)
Nguyen-Tien, Thang
Uppsala University
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Bui-Nghia, Vuong
National Institute of Veterinary Research
Bui-Ngoc, Anh
National Institute of Veterinary Research
Le-Thanh, Duy
National Institute of Veterinary Research
Lundkvist, Ake
Uppsala University
Can-Xuan, Minh
Hanoi Sub-Department of Livestock Production and Animal Health
Nguyen-Thi Thu, Thuy
National Institute Of Hygiene And Epidemiology
Vu-Thi Bich, Hau
National Institute Of Hygiene And Epidemiology
Lee, Hu Suk
International Livestock Research Institute (ILRI)
Nguyen-Viet, Hung
International Livestock Research Institute (ILRI)
International Livestock Research Institute (ILRI)
Uppsala University
Swedish University of Agricultural Sciences, Department of Clinical Sciences

UKÄ Subject classification

Public Health, Global Health, Social Medicine and Epidemiology

Publication Identifiers

DOI: https://doi.org/10.3390/v13030507

URI (permanent link to this page)

https://res.slu.se/id/publ/111624