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Research article2021Peer reviewed

Predictors of reoccurrence of congestive signs within 180 days after successful treatment of the first episode of congestive heart failure in dogs with myxomatous mitral valve disease

Franchini, A.; Abbott, J. A.; Tyrrell, W.; Rosenthal, S.; Lahmers, S.; Menciotti, G.; Crosara, S.; Haggstrom, J.; Borgarelli, M.

Abstract

Introduction: Myxomatous mitral valve disease (MMVD) is the most com-mon cause of left-sided congestive heart failure in dogs. We sought to identify pre-dictors of first reoccurrence of congestive signs (CS) within 180 days in dogs with MMVD and clinically stable heart failure.Animals: A total of 445 dogs affected by stable American College of Veterinary In-ternal Medicine (ACVIM)-Stage-C MMVD were included, 106 in the reoccurrence group (RG) and 339 in no reoccurrence group (NRG). Patients were considered & ldquo;stable & rdquo; if medical treatment had been unchanged for at least 4 weeks since the first identification of CS.Methods: Medical records of dogs with stable ACVIM-Stage-C MMVD included in a registry of dogs affected by MMVD were reviewed. Follow-up was required for inclusion in this investigation. Logistic regression was used to identify clinical and echo cardiographic variables that independently predict first reoccurrence of CS. Results: Baseline left atrial-aortic ratio (p=0.022, OR: 1.89, 90% CI: 1.20-2.98), left ventricular internal diameter at end-diastole (LVIDd_N) (p=0.014, OR: 2.84, 90% CI: 1.41-5.77), peak velocity of early diastolic transmitral flow (p=0.049, OR: 1.81, 90% CI: 1.10-3. 00) and furosemide daily dosage (p=0.039, OR: 1.19, 90% CI: 1.04-1.37) were associated with reoccurrence of CS in univariable analyses. The LVIDd_N (p=0.014) remained significant in the multivariable analysis, but the area under the receiver operator characteristic curve was 0.57.Conclusion: This study failed to identify accurate predictors of reoccurrence of CS. However, dogs with larger value of LVIDd_N are more likely to have reoccurrence of CS within 180 days.(c)& nbsp;2021 Elsevier B.V. All rights reserved.

Keywords

Canine; Degenerative valvular disease; Heart failure; Echocardiography; Valve

Published in

Journal of Veterinary Cardiology
2021, Volume: 34, pages: 112-119
Publisher: ELSEVIER

    UKÄ Subject classification

    Clinical Science

    Publication identifier

    DOI: https://doi.org/10.1016/j.jvc.2020.11.005

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/111821