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Research article - Peer-reviewed, 2021

Concentrations of canine prostate specific esterase, CPSE, at baseline are associated with the relative size of the prostate at three-year follow-up

Holst, Bodil S.; Carlin, Sofia; Fouriez-Lablee, Virginie; Hanas, Sofia; Odling, Sofie; Langborg, Liss-Marie; Ubhayasekera, S. J. Kumari A.; Bergquist, Jonas; Ryden, Jesper; Holmroos, Elin; Hansson, Kerstin

Abstract

BackgroundEnlargement of the prostate is associated with prostatic diseases in dogs, and an estimation of prostatic size is a central part in the diagnostic workup. Ultrasonography is often the method of choice, but biomarkers constitute an alternative. Canine prostate specific esterase (CPSE) shares many characteristics with human prostate specific antigen (PSA) and is related to prostate size. In men with clinical symptoms of prostatic disease, PSA concentrations are related to prostate growth. The aims of the present follow-up study were to evaluate if the concentration of CPSE is associated with future growth of the prostate, and if analysis of a panel of 16 steroids gives further information on prostatic growth. Owners of dogs included in a previous study were 3 years later contacted for a follow-up study that included an interview and a clinical examination. The prostate was examined by ultrasonography. Serum concentrations of CPSE were measured, as was a panel of steroids.ResultsOf the 79 dogs included at baseline, owners of 77 dogs (97%) were reached for an interview, and 22 were available for a follow-up examination. Six of the 79 dogs had clinical signs of prostatic disease at baseline, and eight of the remaining 73 dogs (11%) developed clinical signs between baseline and follow-up, information was lacking for two dogs. Development of clinical signs was significantly more common in dogs with a relative prostate size of >= 2.5 at baseline (n=20) than in dogs with smaller prostates (n=51). Serum concentrations of CPSE at baseline were not associated with the change in prostatic size between baseline and follow-up. Serum concentrations of CPSE at baseline and at follow-up were positively associated with the relative prostatic size (S-rel) at follow-up. Concentrations of corticosterone (P = 0.024), and the class corticosteroids (P = 0.0035) were positively associated with the difference in S-rel between baseline and follow-up.ConclusionsThe results support the use of CPSE for estimating present and future prostatic size in dogs >= 4years, and the clinical usefulness of prostatic size for predicting development of clinical signs of prostatic disease in the dog. The association between corticosteroids and prostate growth warrants further investigation.

Keywords

Dog; Steroids; Corticosteroids; Prostate hyperplasia; Biomarker; Ultrasound

Published in

BMC Veterinary Research
2021, volume: 17, number: 1, article number: 173
Publisher: BMC

Authors' information

Swedish University of Agricultural Sciences, Department of Clinical Sciences
Carlin, Sofia
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Swedish University of Agricultural Sciences, University Animal Hospital
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Ödling, Sofie
Evidensia Specialistdjursjukshuset Strömsholm
Langborg, Liss-Marie
ReDog
Ubhayasekera, S. J. Kumari A.
Uppsala University
Bergquist, Jonas
Uppsala University
Swedish University of Agricultural Sciences, Department of Energy and Technology
Holmroos, Elin
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Swedish University of Agricultural Sciences, Department of Clinical Sciences

UKÄ Subject classification

Clinical Science

Publication Identifiers

DOI: https://doi.org/10.1186/s12917-021-02874-1

URI (permanent link to this page)

https://res.slu.se/id/publ/111915