Lunha, Kamonwan
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Abstract
Antibiotics are freqeuently used in the livestock sector in low- and middle-income countries for treatment, prophylaxis, and growth promotion. However, there is limited information into the zoonotic prevalence and dissemination patterns of antimicrobial resistance (AMR) within these environments. In this study we used pig farming in Thailand as a model to explore AMR; 156 pig farms were included, comprising of small-sized (= 100 sows) farms, where bacterial isolates were selectively cultured from animal rectal and human fecal samples. Bacterial isolates were subjected to antimicrobial susceptibility testing (AST), and whole-genome sequencing. Our results indicate extensive zoonotic sharing of antibiotic resistance genes (ARGs) by horizontal gene transfer. Resistance to multiple antibiotics was observed with higher prevalence in medium-scale farms. Zoonotic transmission of colistin resistance in small-scale farms had a dissemination gradient from pigs to handlers to non-livestock contacts. We highly recommend reducing the antimicrobial use in animals' feeds and medications, especially the last resort drug colistin.
Keywords
one-health approach; antibiotic resistance; zoonotic transmission; E; coli; livestock; pigs; meat-production
Published in
Frontiers in Microbiology
2021, volume: 12, article number: 651461
Publisher: FRONTIERS MEDIA SA
SLU Authors
Jiwakanon, Jatesada
- Khon Kaen University
Magnusson, Ulf
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Associated SLU-program
AMR: Bacteria
Global goals (SDG)
SDG3 Good health and well-being
SDG17 Partnerships for the goals
UKÄ Subject classification
Microbiology
Publication identifier
- DOI: https://doi.org/10.3389/fmicb.2021.651461
Permanent link to this page (URI)
https://res.slu.se/id/publ/111918