Adenovirus-induced alterations in host cell gene expression prior to the onset of viral gene expression

Granberg, Fredrik; Svensson, Catharina; Pettersson, Ulf; Zhao, Hongxing

doi:10.1016/j.virol.2006.06.019

Research article2006Peer reviewedOpen access

Adenovirus-induced alterations in host cell gene expression prior to the onset of viral gene expression

Granberg, Fredrik; Svensson, Catharina; Pettersson, Ulf; Zhao, Hongxing

Abstract

In this report, we have studied gene expression profiles in human primary lung fibroblasts (IMR-90) during the very early phase of an adenovirus infection. Eight out of twelve genes with known functions encoded transcription factors linked to two major cellular processes; inhibition of cell growth (ATF3, ATF4, KLF4, KLF6 and ELK3) and immune response (NR4A1 and CEBPB), indicating that the earliest consequences of an adenovirus infection are growth arrest and induction of an immune response. A time course analysis showed that the induction of these immediate-early response genes was transient and suppressed after the onset of the adenovirus early gene expression. (c) 2006 Elsevier Inc. All rights reserved.

Keywords

adenovirus; microarray; immediate response; gene expression

Published in

Virology
2006, Volume: 353, number: 1, pages: 1-5
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

UKÄ Subject classification

Microbiology in the medical area

Publication identifier

DOI: https://doi.org/10.1016/j.virol.2006.06.019

Permanent link to this page (URI)

https://res.slu.se/id/publ/111958