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Research article - Peer-reviewed, 2022

The ingenious mast cell: Contemporary insights into mast cell behavior and function

Dahlin, Joakim S.; Maurer, Marcus; Metcalfe, Dean D.; Pejler, Gunnar; Sagi-Eisenberg, Ronit; Nilsson, Gunnar

Abstract

Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are important for homeostasis and surveillance of the human system, recognizing both endogenous and exogenous agents, which induce release of a variety of mediators acting on both immune and non-immune cells, including nerve cells, fibroblasts, endothelial cells, smooth muscle cells, and epithelial cells. During recent years, clinical and experimental studies on human mast cells, as well as experiments using animal models, have resulted in many discoveries that help decipher the function of mast cells in health and disease. In this review, we focus particularly on new insights into mast cell biology, with a focus on mast cell development, recruitment, heterogeneity, and reactivity. We also highlight the development in our understanding of mast cell-driven diseases and discuss the development of novel strategies to treat such conditions.

Keywords

allergy; anaphylaxis; animal models; asthma; inflammation; Mast cells; mastocytosis; urticaria

Published in

Allergy
2022, volume: 77, number: 1, pages: 83-99
Publisher: WILEY

Authors' information

Dahlin, Joakim S.
Karolinska University Hospital
Maurer, Marcus
Free University of Berlin
Metcalfe, Dean D.
NIH National Institute of Allergy and Infectious Diseases (NIAID)
Uppsala University
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Sagi-Eisenberg, Ronit
Tel Aviv University
Nilsson, Gunnar
Uppsala University

UKÄ Subject classification

Immunology in the medical area

Publication Identifiers

DOI: https://doi.org/10.1111/all.14881

URI (permanent link to this page)

https://res.slu.se/id/publ/112003