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Review article - Peer-reviewed, 2022

Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

Allam, Venkata Sita Rama Raju; Chellappan, Dinesh Kumar; Jha, Niraj Kumar; Shastri, Madhur D.; Gupta, Gaurav; Shukla, Shakti D.; Singh, Sachin K.; Sunkara, Krishna; Chitranshi, Nitin; Gupta, Vivek; Wich, Peter R.; MacLoughlin, Ronan; Oliver, Brian Gregory George; Wernersson, Sara; Pejler, Gunnar; Dua, Kamal

Abstract

Respiratory diseases, both acute and chronic, are reported to be the leading cause of morbidity and mortality, affecting millions of people globally, leading to high socio-economic burden for the society in the recent decades. Chronic inflammation and decline in lung function are the common symptoms of respiratory diseases. The current treatment strategies revolve around using appropriate anti-inflammatory agents and bronchodilators. A range of anti-inflammatory agents and bronchodilators are currently available in the market; however, the usage of such medications is limited due to the potential for various adverse effects. To cope with this issue, researchers have been exploring various novel, alternative therapeutic strategies that are safe and effective to treat respiratory diseases. Several studies have been reported on the possible links between food and food-derived products in combating various chronic inflammatory diseases. Nutraceuticals are examples of such food-derived products which are gaining much interest in terms of its usage for the well-being and better human health. As a consequence, intensive research is currently aimed at identifying novel nutraceuticals, and there is an emerging notion that nutraceuticals can have a positive impact in various respiratory diseases. In this review, we discuss the efficacy of nutraceuticals in altering the various cellular and molecular mechanisms involved in mitigating the symptoms of respiratory diseases.

Keywords

nutraceuticals; probiotics; minerals; vitamins; antioxidants; phytochemicals; respiratory disease; lung

Published in

Critical Reviews in Food Science and Nutrition
2022, Volume: 62, number: 27, pages: 7576-7590
Publisher: TAYLOR & FRANCIS INC

      SLU Authors

    • Sustainable Development Goals

      SDG3 Good health and well-being

      UKÄ Subject classification

      Respiratory Medicine and Allergy

      Publication identifier

      DOI: https://doi.org/10.1080/10408398.2021.1915744

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/112042