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Review article - Peer-reviewed, 2022

Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

Allam, Venkata Sita Rama Raju; Chellappan, Dinesh Kumar; Jha, Niraj Kumar; Shastri, Madhur D.; Gupta, Gaurav; Shukla, Shakti D.; Singh, Sachin K.; Sunkara, Krishna; Chitranshi, Nitin; Gupta, Vivek; Wich, Peter R.; MacLoughlin, Ronan; Oliver, Brian Gregory George; Wernersson, Sara; Pejler, Gunnar; Dua, Kamal


Respiratory diseases, both acute and chronic, are reported to be the leading cause of morbidity and mortality, affecting millions of people globally, leading to high socio-economic burden for the society in the recent decades. Chronic inflammation and decline in lung function are the common symptoms of respiratory diseases. The current treatment strategies revolve around using appropriate anti-inflammatory agents and bronchodilators. A range of anti-inflammatory agents and bronchodilators are currently available in the market; however, the usage of such medications is limited due to the potential for various adverse effects. To cope with this issue, researchers have been exploring various novel, alternative therapeutic strategies that are safe and effective to treat respiratory diseases. Several studies have been reported on the possible links between food and food-derived products in combating various chronic inflammatory diseases. Nutraceuticals are examples of such food-derived products which are gaining much interest in terms of its usage for the well-being and better human health. As a consequence, intensive research is currently aimed at identifying novel nutraceuticals, and there is an emerging notion that nutraceuticals can have a positive impact in various respiratory diseases. In this review, we discuss the efficacy of nutraceuticals in altering the various cellular and molecular mechanisms involved in mitigating the symptoms of respiratory diseases.


nutraceuticals; probiotics; minerals; vitamins; antioxidants; phytochemicals; respiratory disease; lung

Published in

Critical Reviews in Food Science and Nutrition
2022, volume: 62, number: 27, pages: 7576-7590

Authors' information

Allam, Venkata Sita Rama Raju
Uppsala University
Chellappan, Dinesh Kumar
International Medical University
Jha, Niraj Kumar
Sharda University
Shastri, Madhur D.
University of Tasmania
Guptae, Gaurav
Suresh Gyan Vihar University
Shukla, Shakti D.
University of Newcastle
Singh, Sachin K.
Lovely Professional University
Sunkara, Krishna
John Hunter Hospital
Chitranshi, Nitin
Macquarie University
Gupta, Vivek
Macquarie University
Wich, Peter R.
University of New South Wales Sydney
MacLoughlin, Ronan
Royal College of Surgeons - Ireland
Oliver, Brian Gregory George
Woolcock Institute of Medical Research
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Uppsala University
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Dua, Kamal
University of Technology Sydney

Sustainable Development Goals

SDG3 Good health and wellbeing

UKÄ Subject classification

Respiratory Medicine and Allergy

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