Skip to main content
Research article - Peer-reviewed, 2021

The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus

Schwochow, Doreen; Bornelov, Susanne; Jiang, Tingxing; Li, Jingyi; Gourichon, David; Bed'Hom, Bertrand; Dorshorst, Ben J.; Chuong, Cheng-Ming; Tixier-Boichard, Michele; Andersson, Leif

Abstract

Color patterns within individual feathers are common in birds but little is known about the genetic mechanisms causing such patterns. Here, we investigate the genetic basis for autosomal barring in chicken, a horizontal striping pattern on individual feathers. Using an informative backcross, we demonstrate that the MC1R locus is strongly associated with this phenotype. A deletion at SOX10, underlying the dark brown phenotype on its own, affects the manifestation of the barring pattern. The coding variant L133Q in MC1R is the most likely causal mutation for autosomal barring in this pedigree. Furthermore, a genetic screen across six different breeds showing different patterning phenotypes revealed that the most striking shared characteristics among these breeds were that they all carried the MC1R alleles Birchen or brown. Our data suggest that the presence of activating MC1R mutations enhancing pigment synthesis is an important mechanism underlying pigmentation patterns on individual feathers in chicken. We propose that MC1R and its antagonist ASIP play a critical role for determining within-feather pigmentation patterns in birds by acting as activator and inhibitor possibly in a Turing reaction-diffusion model.

Keywords

chicken; feather patterning; genetics; MC1R; pigmentation; SOX10

Published in

Pigment Cell and Melanoma Research
2021, volume: 34, number: 6, pages: 1015-1028
Publisher: WILEY

Authors' information

Schwochow, Doreen
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Schwochow, Doreen
National Research Institute for Agriculture, Food and Environment (INRAE)
Bornelov, Susanne
University of Cambridge
Jiang, Tingxing
University of Southern California
Li, Jingyi
Virginia Polytechnic Institute and State University
Gourichon, David
INRAE
Bed'Hom, Bertrand
Universite Paris Saclay
Dorshorst, Ben J.
Virginia Polytechnic Institute and State University
Chuong, Cheng-Ming
University of Southern California
Tixier-Boichard, Michele
Universite Paris Saclay
Andersson, Leif
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Andersson, Leif
Uppsala University
Andersson, Leif
Texas A&M University

UKÄ Subject classification

Animal and Dairy Science

Publication Identifiers

DOI: https://doi.org/10.1111/pcmr.12975

URI (permanent link to this page)

https://res.slu.se/id/publ/112118