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Research article - Peer-reviewed, 2021

Yeasts of the Blastobotrys genus are promising platform for lipid-based fuels and oleochemicals production

Sanya, Daniel Ruben Akiola; Onesime, Djamila; Passoth, Volkmar; Maiti, Mrinal K.; Chattopadhyay, Atrayee; Khot, Mahesh B.


Strains of the yeast genus Blastobotrys (subphylum Saccharomycotina) represent a valuable biotechnological resource for basic biochemistry research, single-cell protein, and heterologous protein production processes. Species of this genus are dimorphic, non-pathogenic, thermotolerant, and can assimilate a variety of hydrophilic and hydrophobic substrates. These can constitute a single-cell oil platform in an emerging bio-based economy as oleaginous traits have been discovered recently. However, the regulatory network of lipogenesis in these yeasts is poorly understood. To keep pace with the growing market demands for lipid-derived products, it is critical to understand the lipid biosynthesis in these unconventional yeasts to pinpoint what governs the preferential channelling of carbon flux into lipids instead of the competing pathways. This review summarizes information relevant to the regulation of lipid metabolic pathways and prospects of metabolic engineering in Blastobotrys yeasts for their application in food, feed, and beyond, particularly for fatty acid-based fuels and oleochemicals.


Oleaginous yeasts; Recombinant proteins; Biofuels; Blastobotrys genus; Lipid feedstock; Metabolic engineering

Published in

Applied Microbiology and Biotechnology
Publisher: SPRINGER

Authors' information

Sanya, Daniel Ruben Akiola
Universite Paris Saclay
Onesime, Djamila
Universite Paris Saclay
Swedish University of Agricultural Sciences, Department of Molecular Sciences
Maiti, Mrinal K.
Indian Institute of Technology System (IIT System)
Chattopadhyay, Atrayee
Indian Institute of Technology System (IIT System)
Khot, Mahesh B.
Universidad de Concepcion

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