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Research article - Peer-reviewed, 2021

Wild ungulate species differ in their contribution to the transmission of Ixodes ricinus-borne pathogens

Fabri, Nannet D.; Sprong, Hein; Hofmeester, Tim R.; Heesterbeek, Hans; Donnars, Bjorn F.; Widemo, Fredrik; Ecke, Frauke; Cromsigt, Joris P. G. M.

Abstract

Background Several ungulate species are feeding and propagation hosts for the tick Ixodes ricinus as well as hosts to a wide range of zoonotic pathogens. Here, we focus on Anaplasma phagocytophilum and Borrelia burgdorferi (s.l.), two important pathogens for which ungulates are amplifying and dilution hosts, respectively. Ungulate management is one of the main tools to mitigate human health risks associated with these tick-borne pathogens. Across Europe, different species of ungulates are expanding their ranges and increasing in numbers. It is currently unclear if and how the relative contribution to the life-cycle of I. ricinus and the transmission cycles of tick-borne pathogens differ among these species. In this study, we aimed to identify these relative contributions for five European ungulate species. Methods We quantified the tick load and collected ticks and spleen samples from hunted fallow deer (Dama dama, n = 131), moose (Alces alces, n = 15), red deer (Cervus elaphus, n = 61), roe deer (Capreolus capreolus, n = 30) and wild boar (Sus scrofa, n = 87) in south-central Sweden. We investigated the presence of tick-borne pathogens in ticks and spleen samples using real-time PCR. We determined if ungulate species differed in tick load (prevalence and intensity) and in infection prevalence in their tissue as well as in the ticks feeding on them. Results Wild boar hosted fewer adult female ticks than any of the deer species, indicating that deer are more important as propagation hosts. Among the deer species, moose had the lowest number of female ticks, while there was no difference among the other deer species. Given the low number of infected nymphs, the relative contribution of all ungulate species to the transmission of B. burgdorferi (s.l.) was low. Fallow deer, red deer and roe deer contributed more to the transmission of A. phagocytophilum than wild boar. Conclusions The ungulate species clearly differed in their role as a propagation host and in the transmission of B. burgdorferi and A. phagocytophilum. This study provides crucial information for ungulate management as a tool to mitigate zoonotic disease risk and argues for adapting management approaches to the local ungulate species composition and the pathogen(s) of concern. Graphic abstract

Keywords

Anaplasma phagocytophilum; Borrelia burgdorferi (s.l.); Ixodes ricinus; Ungulate management; Zoonotic disease risk

Published in

Parasites and Vectors
2021, volume: 14, number: 1, article number: 360

Authors' information

Fabri, Nannet
Utrecht University
Fabri, Nannet
Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies
Sprong, Hein
Netherlands National Institute for Public Health and the Environment
Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies
Heesterbeek, Hans
Utrecht University
Donnars, Bjorn F.
Utrecht University
Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies
Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies
Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies
Utrecht University
Nelson Mandela University

Associated SLU-program

SLU Future One Health

Sustainable Development Goals

SDG15 Life on land
SDG3 Good health and wellbeing

UKÄ Subject classification

Ecology

Publication Identifiers

DOI: https://doi.org/10.1186/s13071-021-04860-w

URI (permanent link to this page)

https://res.slu.se/id/publ/112929