Research article - Peer-reviewed, 2021
In Vivo Versus In Vitro Degradation of a 3D Printed Resorbable Device for Ligation of Vascular Tissue in Horses
Adolfsson, Karin H.; Sjoberg, Ida; Hoglund, Odd V.; Wattle, Ove; Hakkarainen, MinnaAbstract
A resorbable 3D printed polydioxanone (PDO) device is manufactured to facilitate ligation of vascular tissue during surgery. The device must provide sufficient mechanical performance throughout the healing period. Therefore, degradation and mechanical performance of the device are investigated as a function of in vivo and in vitro aging. During aging the PDO device released cyclic and linear water-soluble products. In vivo aging resulted in higher relative number of linear oligomers in comparison to in vitro aging. A major loss of mechanical performance is observed after only 10 days in vivo and the Young's modulus (E) and tensile strength at break (sigma(b)) decreased by 28% and 54%, respectively. This is in contrast to in vitro aging, where no loss of mechanical properties is observed during the same period. The in vivo aged devices exhibit clear holes in the matrices after 28 days, while apparent cracks are observed first after 140 days in vitro. These results highlight the sensitivity of the degradation process of resorbable devices with regards to the interactions of the device with the surrounding environment (tissues) and demonstrate the importance of in vivo testing as compliment to in vitro testing before clinical use of devices.Keywords
3D printing; biomedical materials; degradation products; polydioxanone; resorbable devicePublished in
Macromolecular Bioscience2021, volume: 21, number: 10, article number: 2100164
Publisher: WILEY-V C H VERLAG GMBH
Authors' information
Adolfsson, Karin H.
Royal Institute of Technology
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Hakkarainen, Minna
Royal Institute of Technology
UKÄ Subject classification
Biomaterials Science
Publication Identifiers
DOI: https://doi.org/10.1002/mabi.202100164
URI (permanent link to this page)
https://res.slu.se/id/publ/113266