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Research article - Peer-reviewed, 2021

Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum

Hien, Domonbabele F. D. S.; Pare, Prisca S. L.; Cooper, Amanda; Koama, Benjamin K.; Guissou, Edwige; Yameogo, Koudraogo B.; Yerbanga, Rakiswende S.; Farrell, Iain W.; Ouedraogo, Jean B.; Gnankine, Olivier; Ignell, Rickard; Cohuet, Anna; Dabire, Roch K.; Stevenson, Philip C.; Lefevre, Thierry;

Abstract

Background: Besides feeding on blood, females of the malaria vector Anopheles gambiae sensu lato readily feed on natural sources of plant sugars. The impact of toxic secondary phytochemicals contained in plant-derived sugars on mosquito physiology and the development of Plasmodium parasites remains elusive. The focus of this study was to explore the influence of the alkaloid ricinine, found in the nectar of the castor bean Ricinus communis, on the ability of mosquitoes to transmit Plasmodium falciparum.Methods: Females of Anopheles gambiae and its sibling species Anopheles coluzzii were exposed to ricinine through sugar feeding assays to assess the effect of this phytochemical on mosquito survival, level of P. falciparum infection and growth rate of the parasite.Results: Ricinine induced a significant reduction in the longevity of both Anopheles species. Ricinine caused acceleration in the parasite growth rate with an earlier invasion of the salivary glands in both species. At a concentration of 0.04 g l(-1) in An. coluzzii, ricinine had no effect on mosquito infection, while 0.08 g l(-1) ricinine-5% glucose solution induced a 14% increase in An. gambiae infection rate.Conclusions: Overall, our findings reveal that consumption of certain nectar phytochemicals can have unexpected and contrasting effects on key phenotypic traits that govern the intensity of malaria transmission. Further studies will be required before concluding on the putative role of ricinine as a novel control agent, including the development of ricinine-based toxic and transmission-blocking sugar baits. Testing other secondary phytochemicals in plant nectar will provide a broader understanding of the impact which plants can have on the transmission of vector-borne diseases.

Keywords

Plasmodium falciparum; Anopheles coluzzii; Anopheles gambiae; Ricinine; Malaria transmission; Transmission-blocking strategies

Published in

Parasites and Vectors

2021, volume: 14, number: 1, article number: 479
Publisher: BMC

Authors' information

Hien, Domonbabele F. D. S.
Inst Rech Sci Sante IRSS
Hien, Domonbabele F. D. S.
Universite de Montpellier
Hien, Domonbabele F. D. S.
Lab Mixte Int Sur Vecteurs LAMIVECT
Pare, Prisca S. L.
Inst Rech Sci Sante IRSS
Pare, Prisca S. L.
Univ Joseph KI ZERBO
Pare, Prisca S. L.
Universite de Montpellier
Cooper, Amanda
Royal Botanic Gardens, Kew
Koama, Benjamin K.
Inst Rech Sci Sante IRSS
Koama, Benjamin K.
Univ Nazi Boni
Guissou, Edwige
Lab Mixte Int Sur Vecteurs LAMIVECT
Guissou, Edwige
Inst Rech Sci Sante IRSS
Guissou, Edwige
Universite de Montpellier
Yameogo, Koudraogo B.
Inst Rech Sci Sante IRSS
Yameogo, Koudraogo B.
Lab Mixte Int Sur Vecteurs LAMIVECT
Yerbanga, Rakiswende S.
Inst Rech Sci Sante IRSS
Yerbanga, Rakiswende S.
Lab Mixte Int Sur Vecteurs LAMIVECT
Farrell, Iain W.
Royal Botanic Gardens, Kew
Ouedraogo, Jean B.
Inst Rech Sci Sante IRSS
Gnankine, Olivier
Univ Joseph KI ZERBO
Swedish University of Agricultural Sciences, Department of Plant Protection Biology

Sustainable Development Goals

SDG3 Good health and wellbeing

UKÄ Subject classification

Zoology
Ecology

Publication Identifiers

DOI: https://doi.org/10.1186/s13071-021-04992-z

URI (permanent link to this page)

https://res.slu.se/id/publ/113762