Skip to main content
Research article - Peer-reviewed, 2021

AA amyloid in human food chain is a possible biohazard

Rising, Anna; Gherardi, Paola; Chen, Gefei; Johansson, Jan; Oskarsson, Marie E.; Westermark, Gunilla T.; Westermark, Per


AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we show that meat from Swedish and Italian cattle for consumption by humans often contains AA amyloid and that bovine AA fibrils efficiently cross-seed human amyloid beta peptide, associated with Alzheimer's disease.

Published in

Scientific Reports
2021, volume: 11, number: 1, article number: 21069

Authors' information

Karolinska Institute
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Gherardi, Paola
Azienda Unità Sanitaria Locale Di Piacenza
Chen, Gefei
Karolinska Institutet
Johansson, Jan
Karolinska Institutet
Oskarsson, Marie E.
Uppsala University
Westermark, Gunilla T.
Uppsala University
Westermark, Per
Uppsala University

UKÄ Subject classification

Biochemistry and Molecular Biology

Publication Identifiers


URI (permanent link to this page)