Research article - Peer-reviewed, 2021
AA amyloid in human food chain is a possible biohazard
Rising, Anna; Gherardi, Paola; Chen, Gefei; Johansson, Jan; Oskarsson, Marie E.; Westermark, Gunilla T.; Westermark, PerAbstract
AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we show that meat from Swedish and Italian cattle for consumption by humans often contains AA amyloid and that bovine AA fibrils efficiently cross-seed human amyloid beta peptide, associated with Alzheimer's disease.Published in
Scientific Reports2021, volume: 11, number: 1, article number: 21069
Publisher: NATURE PORTFOLIO
Authors' information
Karolinska Institute
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Gherardi, Paola
Azienda Unità Sanitaria Locale Di Piacenza
Chen, Gefei
Karolinska Institutet
Johansson, Jan
Karolinska Institutet
Oskarsson, Marie E.
Uppsala University
Westermark, Gunilla T.
Uppsala University
Westermark, Per
Uppsala University
UKÄ Subject classification
Biochemistry and Molecular Biology
Neurosciences
Publication Identifiers
DOI: https://doi.org/10.1038/s41598-021-00588-w
URI (permanent link to this page)
https://res.slu.se/id/publ/114384