AA amyloid in human food chain is a possible biohazard

Abstract

AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we show that meat from Swedish and Italian cattle for consumption by humans often contains AA amyloid and that bovine AA fibrils efficiently cross-seed human amyloid beta peptide, associated with Alzheimer's disease.

Published in

Scientific Reports
2021, volume: 11, number: 1, article number: 21069
Publisher: NATURE PORTFOLIO

SLU Authors

• Rising, Anna

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    
  • Karolinska Institute

UKÄ Subject classification

Biochemistry
Neurosciences
Molecular Biology

Publication identifier

• DOI: https://doi.org/10.1038/s41598-021-00588-w

Permanent link to this page (URI)

https://res.slu.se/id/publ/114384