Vargmar, Karin
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Abstract
Regulation of fluid balance is pivotal during surgery and anesthesia and affects patient morbidity, mortality, and hospital length of stay. Retention of sodium and water is known to occur during surgery but the mechanisms are poorly defined. In this study, we explore how the volatile anesthetic sevoflurane influences renal function by affecting renal sympathetic nerve activity (RSNA). Our results demonstrate that sevoflurane induces renal sodium and water retention during pediatric anesthesia in association with elevated plasma concentration of renin but not arginine–vasopressin. The mechanisms are further explored in conscious and anesthetized ewes where we show that RSNA is increased by sevoflurane compared with when conscious. This is accompanied by renal sodium and water retention and decreased renal blood flow (RBF). Finally, we demonstrate that renal denervation normalizes renal excretory function and improves RBF during sevoflurane anesthesia in sheep. Taken together, this study describes a novel role of the renal sympathetic nerves in regulating renal function and blood flow during sevoflurane anesthesia.
Keywords
acute Kidney Injury (AKI); anesthesia; oliguria; urine output; ischemia; surgery; renal failure; kidney
Published in
Function
2021, volume: 2, number: 6, article number: zqab042
SLU Authors
Valarcher, Jean-Francois
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
UKÄ Subject classification
Anesthesiology and Intensive Care
Publication identifier
- DOI: https://doi.org/10.1093/function/zqab042
Permanent link to this page (URI)
https://res.slu.se/id/publ/115176