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Research article2022Peer reviewedOpen access

Emergence of methicillin resistance predates the clinical use of antibiotics

Larsen, Jesper; Raisen, Claire L.; Ba, Xiaoliang; Sadgrove, Nicholas J.; Padilla-Gonzalez, Guillermo F.; Simmonds, Monique S. J.; Loncaric, Igor; Kerschner, Heidrun; Apfalter, Petra; Hartl, Rainer; Deplano, Ariane; Vandendriessche, Stien; Bolfikova, Barbora Cerna; Hulva, Pavel; Arendrup, Maiken C.; Hare, Rasmus K.; Barnadas, Celine; Stegger, Marc; Sieber, Raphael N.; Skov, Robert L.;
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Abstract

The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics(1). Here we show that particular lineages of methicillin-resistant Staphylococcus aureus-a notorious human pathogen-appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two beta-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development.

Published in

Nature
2022, Volume: 602, number: 7895, pages: 135-141
Publisher: NATURE PORTFOLIO

    Sustainable Development Goals

    SDG3 Good health and well-being

    UKÄ Subject classification

    Clinical Science

    Publication identifier

    DOI: https://doi.org/10.1038/s41586-021-04265-w

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/115381