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Research article2022Peer reviewedOpen access

Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation

Sturm, Sabina; Weber, Klaus; Klinc, Primoz; Sporndly-Nees, Ellinor; Fakhrzadeh, Azadeh; Knific, Tanja; Skibin, Andrej; Fialova, Vera; Okazaki, Yoshimasa; Razinger, Tanja; Laufs, Jurgen; Kreutzer, Robert; Pogacnik, Milan; Svara, Tanja; Cerkvenik-Flajs, Vesna


Bisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has been reported by many researchers to induce male reproductive toxicity in different experimental models. In this study, we investigated whether long-term exposure for two months to 25 mu g/kg body weight (low dose) of BPA affects spermatogenesis or sperm quality in young Istrian Pramenka rams exposed via diet. We evaluated body and testicular weights, histopathology of testes and epididymides, and sperm analyses, and compared these parameters between the group of treated rams and the control group of rams. Although there were some differences between the two groups, these differences were not large or statistically significant. The only statistically significant difference was the lower epithelial height of seminiferous tubules in treated rams, compared to control rams. In addition to assessing toxicity, BPA concentrations in the blood plasma of treated rams were determined after the first administration, and the toxicokinetic parameters of total BPA were calculated. In this study, no major signs of altered reproduction in rams were detected.


bisphenol A; rams; toxicokinetics; male toxicity; sperm

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2022, Volume: 10, number: 5, article number: 224
Publisher: MDPI

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