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Research article - Peer-reviewed, 2022

Non-canonical odor coding in the mosquito

Herre, Margaret; Goldman, Olivia, V; Lu, Tzu-Chiao; Caballero-Vidal, Gabriela; Qi, Yanyan; Gilbert, Zachary N.; Gong, Zhongyan; Morita, Takeshi; Rahiel, Saher; Ghaninia, Majid; Ignell, Rickard; Matthews, Benjamin J.; Li, Hongjie; Vosshall, Leslie B.; Younger, Meg A.;

Abstract

Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including dengue when they feed on human blood. Mosquitoes are intensely attracted to body odor and carbon dioxide, which they detect using ionotropic chemosensory receptors encoded by three large multi-gene families. Genetic mutations that disrupt the olfactory system have modest effects on human attraction, suggesting redundancy in odor cod-ing. The canonical view is that olfactory sensory neurons each express a single chemosensory receptor that defines its ligand selectivity. We discovered that Ae. aegypti uses a different organizational principle, with many neurons co-expressing multiple chemosensory receptor genes. In vivo electrophysiology demon-strates that the broad ligand-sensitivity of mosquito olfactory neurons depends on this non-canonical co-expression. The redundancy afforded by an olfactory system in which neurons co-express multiple chemosensory receptors may increase the robustness of the mosquito olfactory system and explain our long-standing inability to disrupt the detection of humans by mosquitoes.

Published in

Cell

2022, volume: 185, number: 17, pages: 3104-3123
Publisher: CELL PRESS

Authors' information

Herre, Margaret
Rockefeller University
Goldman, Olivia
Rockefeller University
Lu, Tzu-Chiao
Baylor College of Medicine
Caballero Vidal, Gabriela
Swedish University of Agricultural Sciences, Department of Plant Protection Biology
Qi, Yanyan
Baylor College of Medicine
Gilbert, Zachary N.
Rockefeller University
Gong, Zhongyan
Rockefeller University
Gong, Zhongyan
University of British Columbia
Morita, Takeshi
Howard Hughes Medical Institute
Morita, Takeshi
Rockefeller University
Rahiel, Saher
Rockefeller University
Swedish University of Agricultural Sciences, Department of Plant Protection Biology
Swedish University of Agricultural Sciences, Department of Plant Protection Biology
Matthews, Benjamin J.
Rockefeller University
Li, Hongjie
Baylor College of Medicine
Vosshall, Leslie B.
The Rockefeller University
Younger, Meg A.
Boston University
Younger, Meg A.
University of California Berkeley
Younger, Meg A.
Rockefeller University

Sustainable Development Goals

SDG3 Good health and wellbeing

UKÄ Subject classification

Cell and Molecular Biology

Publication Identifiers

DOI: https://doi.org/10.1016/j.cell.2022.07.024

URI (permanent link to this page)

https://res.slu.se/id/publ/119021