Skip to main content
Research article - Peer-reviewed, 2022

Genetic parameters of colostrum and calf serum antibodies in Swedish dairy cattle

Cordero, Juan; De Koning, Dirk-Jan; Tråven, Madeleine; de Haan, Therese; Jouffroy, Mathilde; Larsson, Andrea; Myrthe, Aline; Arts, Joop A. J.; Parmentier, Henk K.; Bovenhuis, Henk; Wensman, Jonas Johansson;

Abstract

Background
A sufficient IgG content in the colostrum is essential for the newborn calf, as it provides passive immunity which substantially affects the probability of survival during rearing. Failure of passive transfer (FPT) occurs when a calf does not absorb enough antibodies from the colostrum and is defined by an IgG concentration in calf serum lower than 10 g/L. Apart from delayed access to colostrum, FPT can be due to a low production of IgG in the mother or poor IgG absorption by the calf. The aim of this study was to estimate the genetic background of antibody levels and indicator traits for antibodies in the colostrum and calf serum, and their correlation with milk production.

Results
Colostrum data were available for 1340 dairy cows with at least one calving and calf serum data were available for 886 calves from these cows. Indicator traits for antibody concentrations were estimated using refractometry (a digital Brix refractometer for colostrum and an optical refractometer for serum), and enzyme-linked immunosorbent assays (ELISA) were used to determine the levels of total IgG and natural antibodies (NAb) of various antibody isotypes in the colostrum and calf serum. Colostrum traits had heritabilities ranging from 0.16 to 0.31 with repeatabilities ranging from 0.21 to 0.55. Brix percentages had positive genetic correlations with all colostrum antibody traits including total IgG (0.68). Calf serum antibody concentrations had heritabilities ranging from 0.25 to 0.59, with a significant maternal effect accounting for 17 to 27% of the variance. When later in life calves produced their first lactation, the lactation average somatic cell score was found to be negatively correlated with NAb levels in calf serum.

Conclusions
​​​​​​​Our results suggest that antibody levels in the colostrum and calf serum can be increased by means of selection.

Published in

Genetics Selection Evolution

2022, volume: 54, number: 1, article number: 68

Authors' information

Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Wageningen University and Research
Servicio Nacional de Salud Animal (SENASA)
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Swedish University of Agricultural Sciences, Department of Clinical Sciences
de Haan, Therese
No organisation
Jouffroy, Mathilde
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Jouffroy, Mathilde
AgroSup Dijon
Larsson, Andrea
No organisation
Myrthe, Aline
Superior School of Agricultures
Arts, Joop A. J.
Wageningen University and Research
Parmentier, Henk K.
Wageningen University and Research
Bovenhuis, Henk
Wageningen University and Research
Wensman, Jonas Johansson (Johansson Wensman, Jonas)
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Wensman, Jonas Johansson (Johansson Wensman, Jonas)
National Veterinary Institute SVA

UKÄ Subject classification

Genetics and Breeding

Publication Identifiers

DOI: https://doi.org/10.1186/s12711-022-00758-y

URI (permanent link to this page)

https://res.slu.se/id/publ/119368