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Research article - Peer-reviewed, 2023

Genetics of tibia bone properties of crossbred commercial laying hens in different housing systems

Johnsson, Martin; Wall, Helena; Lopes Pinto, Fernando A; Fleming, Robert H.; McCormack, Heather A.; Benavides-Reyes, Cristina; Dominguez-Gasca, Nazaret; Sanchez-Rodriguez, Estefania; Dunn, Ian C.; Rodriguez-Navarro, Alejandro B.

Abstract

Osteoporosis and bone fractures are a severe problem for the welfare of laying hens, with genetics and environment, such as housing system, each making substantial contributions to bone strength. In this work, we performed genetic analyses of bone strength, bone mineral density, and bone composition, as well as body weight, in 860 commercial crossbred laying hens from 2 different companies, kept in either furnished cages or floor pens. We compared bone traits between housing systems and crossbreds and performed a genome-wide association study of bone properties and body weight. As expected, the 2 housing systems produced a large difference in bone strength, with layers housed in floor pens having stronger bones. These differences were accompanied by differences in bone geometry, mineralization, and chemical composition. Genome scans either combining or independently analyzing the 2 housing systems revealed no genome-wide significant loci for bone breaking strength. We detected 3 loci for body weight that were shared between the housing systems on chromosomes 4, 6, and 27 (either genome-wide significant or suggestive) and these coincide with associations for bone length. In summary, we found substantial differences in bone strength, content, and composition between hens kept in floor pens and furnished cages that could be attributed to greater physical activity in pen housing. We found little evidence for large-effect loci for bone strength in commercial crossbred hens, consistent with a highly polygenic architecture for bone strength in the production environment. The lack of consistent genetic associations between housing systems in combination with the differences in bone phenotypes could be due to gene-by-environment interactions with housing system or a lack of power to detect shared associations for bone strength.

Keywords

bone; quantitative genetics; gene-by-environment

Published in

G3
2023, volume: 13, number: 2, article number: jkac302

Authors' information

Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Swedish University of Agricultural Sciences, Department of Animal Nutrition and Management
Lopes Pinto, Fernando A
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Fleming, Robert H.
University of Edinburgh
McCormack, Heather A.
University of Edinburgh
Benavides-Reyes, Cristina
University of Granada
Dominguez-Gasca, Nazaret
University of Granada
Sanchez-Rodriguez, Estefania
University of Granada
Dunn, Ian C.
University of Edinburgh
Rodriguez-Navarro, Alejandro B.
University of Granada
Kindmark, Andreas
Uppsala University
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics

UKÄ Subject classification

Animal and Dairy Science

Publication Identifiers

DOI: https://doi.org/10.1093/g3journal/jkac302

URI (permanent link to this page)

https://res.slu.se/id/publ/120476