- Department of Plant Breeding, Swedish University of Agricultural Sciences
Evolutionary dynamics and adaptive benefits of deleterious mutations in crop gene pools
Dwivedi, Sangam L.; Heslop-Harrison, Pat; Spillane, Charles; McKeown, Peter C.; Edwards, David; Goldman, Irwin; Ortiz, Rodomiro
Deleterious mutations are common in plant genomes and present both challenges and opportunities for domesticated crops.
While many deleterious mutations can negatively impact crop performance, some deleterious mutations are associated with breeding-relevant phenomena, such as heterosis, genetic variation, and key loss-of-function domestication traits that underpin crop production. Breeding may hasten the accumulation of deleterious variants.
Crop species vary in their pattern and distribution of deleterious mutations, and differences are noted among mating systems, ploidy levels, and propagation systems. Current efforts focus on predicting functional consequences of deleterious mutations on a genome-wide scale and comparing the effects across species.
Strategies for removal of deleterious variants with techniques such as gene editing may facilitate breeding and accelerate the redomestication of crops from wild species.
crop improvement; deleterious variants; genome editing; genomic prediction; HapMaps; mating system; propagation; selective sweeps; wild relatives
Trends in Plant Science
2023, Volume: 28, number: 6, pages: 685-697
Sustainable Development Goals
SDG2 Zero hunger
UKÄ Subject classification
Genetics and Breeding
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