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Research article - Peer-reviewed, 2023

A 21-Day Individual Rehabilitation Exercise Training Program Changes Irisin, Chemerin, and BDNF Levels in Patients after Hip or Knee Replacement Surgery

Skrzep-Poloczek, Bronislawa; Idzik, Maciej; Michalczyk, Katarzyna; Chelmecka, Elzbieta; Kukla, Michal; Zalejska-Fiolka, Jolanta; Poloczek, Jakub; Bogielski, Bartosz; Jochem, Jerzy; Nowak, Damian; Stygar, Dominika


Osteoarthritis (OA) is the most frequent worldwide cause of adult population disabilities. The study evaluated the effects of a 21-day individual rehabilitation exercise training program focused on improving patients' functional capacity. The study analyzed the changes in irisin, chemerin, and BDNF serum levels in 36 OA patients subjected to an individually-adjusted rehabilitation program 90 days after surgical hip or knee replacement. The changes in irisin, chemerin, and BDNF serum levels were measured using enzyme-linked immunosorbent assay (ELISA) kits. A 21-day individual rehabilitation exercise training program significantly increased irisin and BDNF, and decreased chemerin serum levels. The presented study indicates that individually-adjusted exercise training is an important modulator influencing serum levels of anti- and pro-inflammatory factors, leading to positive clinical outcomes in osteoarthritis therapy. Selected factors are considered potential markers of various pathophysiological conditions. The presented study brings new details to the discussion.


brain-derived neurotrophic factor (BDNF); chemerin; hip or knee replacement surgery; irisin; individual rehabilitation exercise training; osteoarthritis

Published in

Journal of Clinical Medicine
2023, Volume: 12, number: 15, article number: 4881
Publisher: MDPI

    UKÄ Subject classification

    Rheumatology and Autoimmunity

    Publication Identifiers


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