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Research article2023Peer reviewedOpen access

Bone Biomarker in Feedlot Cattle from Two Different Production Systems

Lützelschwab, Claudia; Adepu, Saritha; Ekman, Stina; Skiöldebrand, Eva; Crain, Scott; Coffey, Robert


The rapid growth rate in feedlot cattle is likely to promote joint abnormalities like osteochondrosis dissecans (OCD) and osteoarthritis (OA) with subsequent lameness. We have identified a small leucine-rich repeat proteoglycan (SLRP) biomarker at cleavage site 262GLGHNQIRM (BGN262) arising from the fragmentation of biglycan (BGN) in subchondral bone associated with OA. With a validated custom-made ELISA, BGN262 has been quantified in serum from cattle. The concentration of BGN262 in serum from cattle raised in the conventional and all-natural production systems increased at harvest compared to the starting period. The limitation of the study is the small sample size. However, the promising results encourage a further evaluation of BGN262 and its potential as a biomarker for subchondral bone pathology in cattle.


Osteochondrosis; Osteoarthritis; Lameness; Cattle; Biglycan; Biomarker

Published in

Food science & nutrition research
2023, Volume: 6, number: 2