Skip to main content
SLU publication database (SLUpub)

Research article2024Peer reviewedOpen access

Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study

Asadipour, Ali; Pourshojaei, Yaghoub; Mansouri, Moein; Mahdavizadeh, Elham; Irajie, Cambyz; Mottaghipisheh, Javad; Faghih-Mirzaei, Ehsan; Mahdavi, Mohammad; Iraji, Aida

Abstract

In this article, we present the design and synthesis of amino-7,8-dihydro-4H-chromenone derivatives as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for the management of Alzheimer's disease (AD). The target compounds were evaluated against AChE and BChE in vitro, and 4k exhibited good potency against BChE (IC50 = 0.65 +/- 0.13 mu M) compared with donepezil used as a positive control. Kinetic studies revealed that compound 4k exhibited a competitive-type inhibition with a K i value of 0.55 mu M. Molecular docking and molecular dynamics simulations further supported the rationality of our design strategy, as 4k showed promising binding interactions with the active sites of BChE. Overall, our findings highlight the potential of amino-7,8-dihydro-4H-chromenone derivatives as promising candidates for developing novel therapeutics targeting cholinesterase in managing AD.

Keywords

Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Chromenone; Kinetic; Molecular dynamics

Published in

BMC Chemistry
2024, Volume: 18, number: 1, article number: 70Publisher: BMC

    UKÄ Subject classification

    Medicinal Chemistry

    Publication identifier

    DOI: https://doi.org/10.1186/s13065-024-01170-x

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/129351