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Conference paper2022Peer reviewedOpen access

Host variation in susceptibility to lumpy skin disease: gene expression analyses of experimentally infected cows

Van Borm, S.; Klingström, T.; Niazi, A.; et al.

Abstract

Lumpy Skin Disease (LSD) is becoming a global threat to cattle and related species. It requires annual vaccination to prevent further outbreaks. There is host variation in the response to infection both in field studies and under carefully controlled artificial infections. Here, we study the gene expression response in whole blood at four time points before and after experimental infection with LSD virus in five cows with divergent disease outcomes. Differentially expressed genes (FDR<0.05) were identified for comparisons between LSD symptomatic and asymptomatic animals at all time points as well as between time points for symptomatic animals. Gene set enrichment showed a role of oxidative phosphorylation as well as a range of disease pathways. While preliminary, these results are the first ever study of host transcriptomes related to LSD.

Published in

Title: Proceedings of the12th World Congress on Genetics applied to Livestock Production (WCGALP) : Technical and species orientated innovations in animal breeding,and contribution of genetics to solving societal challenges
eISBN: 978-90-8686-940-4Publisher: Wageningen Academic Publishers

Conference

12th World Congress on Genetics Applied to Livestock Production (WCGALP), 2022-07-03, Wageningen, The Netherlands

      SLU Authors

    • Sustainable Development Goals

      SDG2 Zero hunger
      SDG3 Good health and well-being

      UKÄ Subject classification

      Genetics and Breeding
      Animal and Dairy Science
      Bioinformatics and Systems Biology

      Publication identifier

      DOI: https://doi.org/10.3920/978-90-8686-940-4_154

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/132638