Research article - Peer-reviewed, 2007
Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis
Jeffries TW, Grigoriev IV, Grimwood J, Laplaza JM, Aerts A, Salamov A, Schmutz J, Lindquist E, Dehal P, Shapiro H, Jin YS, Passoth V, Richardson PMAbstract
Xylose is a major constituent of plant lignocellulose, and its fermentation is important for the bioconversion of plant biomass to fuels and chemicals. Pichia stipitis is a well-studied, native xylose-fermenting yeast. The mechanism and regulation of xylose metabolism in P. stipitis have been characterized and genes from P. stipitis have been used to engineer xylose metabolism in Saccharomyces cerevisiae. We have sequenced and assembled the complete genome of P. stipitis. The sequence data have revealed unusual aspects of genome organization, numerous genes for bioconversion, a preliminary insight into regulation of central metabolic pathways and several examples of colocalized genes with related functions. The genome sequence provides insight into how P. stipitis regulates its redox balance while very efficiently fermenting xylose under microaerobic conditionsPublished in
Nature Biotechnology2007, volume: 25, number: 3, pages: 319-326
Publisher: NATURE PUBLISHING GROUP
Authors' information
Swedish University of Agricultural Sciences, Department of Microbiology
Dehal, P
Grigoriev, I. V.
Jeffries, T. W.
Jin, Y-S
Laplaza, J. M.
Lindquist, E
Richardson, P. M.
Shapiro, H
Aerts, A
Salamov, A
Grimwood, J
Schmutz, J
UKÄ Subject classification
Renewable Bioenergy Research
Agricultural Science
Forest Science
Publication Identifiers
DOI: https://doi.org/10.1038/nbt1290
URI (permanent link to this page)
https://res.slu.se/id/publ/13637