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Research article2006Peer reviewedOpen access

Effects of carprofen on renal function during medetomidine-propofol-isoflurane anesthesia in dogs

Frendin JHM, Bostrom IM, Kampa N, Eksell P, Haggstrom JU, Nyman GC

Abstract

Objective-To investigate effects of carprofen on indices of renal function and results of serum biochemical analyses and effects on cardiovascular variables during medetomidine-propofol-isoflurane anesthesia in dogs. Animals-8 healthy male Beagles. Procedures-A randomized crossover study was conducted with treatments including saline (0.9% NaCl) solution (0.08 mL/kg) and carprofen (4 mg/kg) administered IV Saline solution or carprofen was administered 30 minutes before induction of anesthesia and immediately before administration of medetomidine (20 mu g/kg, IM). Anesthesia was induced with propofol and maintained with inspired isoflurane in oxygen. Blood gas concentrations and ventilation were measured. Cardiovascular variables were continuously monitored via pulse contour cardiac output (CO) measurement. Renal function was assessed via glomerular filtration rate (GFR), renal blood flow (RBF), scintigraphy, serum biochemical analyses, .urinalysis, and continuous CO measurements. Hematologic analysis was performed. Results-Values did not differ significantly between the carprofen and saline solution groups. For both treatments, sedation and anesthesia caused changes in results of serum biochemical and hematologic analyses; a transient, significant increase in urine alkaline phosphatase activity; and blood flow diversion to the kidneys. The GFR increased significantly in both groups despite decreased CO, mean arterial pressure, and absolute RBF variables during anesthesia. Conclusions and Clinical Relevance-Carprofen administered IV before anesthesia did not cause detectable, significant adverse effects on renal function during medetomidine-propofol-isoflurane anesthesia in healthy Beagles

Published in

American Journal of Veterinary Research
2006, Volume: 67, number: 12, pages: 1967-1973 Publisher: AMER VETERINARY MEDICAL ASSOC

      SLU Authors

      • UKÄ Subject classification

      Animal and Dairy Science
      Veterinary Science

      Publication identifier

      DOI: https://doi.org/10.2460/ajvr.67.12.1967

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/14017