Changes in the expression pattern of genes affecting the growth and development of mammary tissue in pregnant Saanen goats in response to dietary fats

Abstract

The period from mid-pregnancy to term is a pivotal phase for the growth and development of the mammary glands. Diets containing unsaturated fat may also influence this process. This study examined the effects of saturated and unsaturated fat supplements on mammary gland growth in Saanen goats. Forty goats were divided into four groups: C- (negative control, no added fat), C+ (positive control, saturated palm oil), SB (Omega-6, roasted soybean), and FS (Omega-3, extruded flaxseed). Blood parameters, histological data, and the expression of genes related to mammary tissue growth and apoptosis were examined. Our findings showed that the C- group had the highest (p

Keywords

Growth factors; Apoptosis; Mammary gland; Supplemental fats; Saanen goat; IGF-I; insulin-like growth factor-1; IGFBP-3; insulin-like growth factor binding; protein-3; IGFBP-5; Bcl-2; B -cell lymphoma-2; TNF-alpha; tumor necrosis factor-alpha; dehydrogenase

Published in

Domestic Animal Endocrinology
2025, volume: 92, article number: 106943
Publisher: ELSEVIER SCIENCE INC

SLU Authors

• Banabazi, Mohammad Hossein

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    
  • Animal Science Research Institute of Iran

UKÄ Subject classification

Medical Bioscience
Animal and Dairy Science

Publication identifier

• DOI: https://doi.org/10.1016/j.domaniend.2025.106943

Permanent link to this page (URI)

https://res.slu.se/id/publ/141702