Research article - Peer-reviewed, 2007
Quantitative structure-activity relationships of pine weevil antifeedants, a Multivariate approach
Sunnerheim K, Nordqvist A, Nordlander G, Borg-Karlson AK, Unelius CR, Bohman B, Nordenhem H, Hellqvist C, Karlen AAbstract
Antifeedant activity of mainly phenylpropanoic, cinnamic, and benzoic acids esters was tested on the pine weevil, Hylobius abiefis (L.). Of 105 compounds screened for activity, 9 phenylpropanoates, 3 cinnamates, and 4 benzoates were found to be highly active antifeeclants. To understand the structure-activity relationships of these compounds, a multivariate analysis study was performed. A number of molecular and substituent descriptors were calculated and correlated to results from two-choice feeding tests with H. abietis. Three local models were developed that had good internal predictive ability. External test sets showed moderate predictivity. In general, low polarity, small size, and high lipophilicity were characteristics for compounds having good antifeeclant activityPublished in
Journal of Agricultural and Food Chemistry2007, volume: 55, number: 23, pages: 9365-9372
Publisher: AMER CHEMICAL SOC
Authors' information
Swedish University of Agricultural Sciences, Department of Entomology
Nordenhem, Henrik
Swedish University of Agricultural Sciences, Department of Entomology
Swedish University of Agricultural Sciences, Department of Entomology
Unelius, C. Rickard
Karlén, Anders
Borg-Karlsson, Anna-Karin
Nordqvist, Anneli
Bohman, Björn
Sunnerheim, Kerstin
UKÄ Subject classification
Forest Science
Environmental Sciences related to Agriculture and Land-use
Publication Identifiers
DOI: https://doi.org/10.1021/ifO70014p
URI (permanent link to this page)
https://res.slu.se/id/publ/15455