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Research article2007Peer reviewed

Quantitative structure-activity relationships of pine weevil antifeedants, a Multivariate approach

Sunnerheim, K; Nordqvist, A; Nordlander, G; Borg-Karlson, AK; Unelius, CR; Bohman, B; Nordenhem, H; Hellqvist, C; Karlen, A

Abstract

Antifeedant activity of mainly phenylpropanoic, cinnamic, and benzoic acids esters was tested on the pine weevil, Hylobius abiefis (L.). Of 105 compounds screened for activity, 9 phenylpropanoates, 3 cinnamates, and 4 benzoates were found to be highly active antifeeclants. To understand the structure-activity relationships of these compounds, a multivariate analysis study was performed. A number of molecular and substituent descriptors were calculated and correlated to results from two-choice feeding tests with H. abietis. Three local models were developed that had good internal predictive ability. External test sets showed moderate predictivity. In general, low polarity, small size, and high lipophilicity were characteristics for compounds having good antifeeclant activity

Published in

Journal of Agricultural and Food Chemistry
2007, volume: 55, number: 23, pages: 9365-9372
Publisher: AMER CHEMICAL SOC

SLU Authors

  • Nordenhem, Henrik

    • Department of Entomology, Swedish University of Agricultural Sciences

  • Hellqvist, Claes

    • Department of Entomology, Swedish University of Agricultural Sciences

UKÄ Subject classification

Forest Science
Environmental Sciences and Nature Conservation

Publication identifier

  • DOI: https://doi.org/10.1021/ifO70014p

Permanent link to this page (URI)

https://res.slu.se/id/publ/15455