Abstract

The major lignan in the unsaponifiable fraction of sesame lipids, sesamin, is known to affect lipid metabolism. For example, sesamin inhibits the clearance of tocopherols, the activity of Delta 5-desaturase during fatty acid metabolism, and reduces cholesterol absorption and biosynthesis. In order to study whether dietary phytosterols, which are known to reduce the absorption of lipid soluble dietary factors, may influence the lipid-modulating effects of sesamin, rats were fed, in a 2x2 Latin-square design, diets containing two concentrations of sesamin and pbytosterols for 4 weeks. Tocopherols and cholesterol were analyzed in plasma and liver and the fatty acid profile was determined in liver lipids. Sesamin increased a-tocopherol concentrations in plasma and liver (p< 0. 001), whereas the phytosterols had no effect. However, an increase in the phytosterol content of the diet resulted in a reduction of the alpha-tocopherol-elevating effect of sesamin in plasma (p< 0. 01). Similarly, sesamin increased the percentage of dihomo-gamma-linolenic acid in liver lipids (p<0.05), which was abolished by the addition of pbytosterols. Neither sesamin nor phytosterols significantly altered cholesterol concentrations in plasma or liver. In conclusion, these results suggest that in rats, dietary phytosterols may interact with sesamin in a way reducing its biological activities

Published in

Current Topics in Nutraceutical Research
2007, Volume: 5, number: 2-3, pages: 93-97
Publisher: NEW CENTURY HEALTH PUBLISHERS, LLC

SLU Authors

• Moazzami, Ali

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    

• Lundh, Torbjörn

  • Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
    

• Kamal-Eldin, Afaf

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science
Food Science


Permanent link to this page (URI)

https://res.slu.se/id/publ/16085