Salmon Hillbertz, Nicolette
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2007Peer reviewed
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs
Hillbertz NHCS, Isaksson M, Karlsson EK, Hellmen E, Pielberg GR, Savolainen P, Wade CM, Von Euler H, Gustafson U, Hedhammar K, Nilsson M, Lindblad-Toh K, Andersson L, Andersson G
Abstract
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development
Published in
Nature Genetics
2007, Volume: 39, number: 11, pages: 1318-1320
Publisher: NATURE PUBLISHING GROUP
Rönnberg, Henrik
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Gustafson, Ulla
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Hedhammar, Åke
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Andersson, Göran
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Hellmén, Eva
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
SLU Authors
UKÄ Subject classification
Veterinary Science
Animal and Dairy Science
Permanent link to this page (URI)
https://res.slu.se/id/publ/16369