Mowbray, Sherry
- Department of Molecular Biology, Swedish University of Agricultural Sciences
Abstract
A microwave-enhanced, palladium-catalyzed protocol for the alpha-arylation of a protected glycine in neat water is described. This reaction proceeds rapidly, under non-inert conditions, to afford a range of phenylglycine derivatives in moderate to good yields. Based on this arylation, a number of aryl L-methionine-SR-sulfoximine (MSO) analogues were prepared and evaluated for their Mycobacterium tuberculosis glutamine synthetase (TB-GS) inhibitory activity
Published in
Combinatorial Chemistry and High Throughput Screening
2007, volume: 10, number: 9, pages: 783-789
Publisher: BENTHAM SCIENCE PUBL LTD
SLU Authors
UKÄ Subject classification
Food Science
Publication identifier
- DOI: https://doi.org/10.2174/138620707783018478
Permanent link to this page (URI)
https://res.slu.se/id/publ/16957