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Conference paper2007Peer reviewed

Flexibility Description of the MET Protein Stalk Based on the Use of Non-Uniform B-Splines

Gedda, Magnus; Svensson, Stina

Abstract

The MET protein controls growth, invasion, and metastasis in cancer cells and is thereby of interest to study, for example from a structural point of view. For individual particle imaging by Cryo-Electron Tomography of the MET protein, or other proteins, dedicated image analysis methods are required to extract information in a robust way as the images have low contrast and resolution (with respect to the size of the imaged structure). We present a method to identify the two parts of the MET protein, Beta-propeller and stalk, using a fuzzy framework. Furthermore, we describe how a representation of the MET stalk, denoted stalk curve, can be identified based on the use of non-uniform B-splines. The stalk curve is used to extract relevant geometrical information about the stalk, e.g., to facilitate curvature and length measurements

Keywords

Cryo-ET; fuzzy distance; geometrical feature extraction

Published in

Lecture Notes in Computer Science
2007, pages: 173-180 Title: Lecture Notes in Computer Science
ISBN: 978-3-540-74271-5
Publisher: Springer Berlin / Heidelberg

Conference

12th International Conference on Computer Analysis of Images and Patterns

      SLU Authors

    • Svensson, Stina

      • Centre for Image Analysis, Swedish University of Agricultural Sciences

    Publication identifier

    DOI: https://doi.org/10.1007/978-3-540-74272-2_22

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/17120