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Research article - Peer-reviewed, 2003

MZF6D, a novel KRAB zinc-finger gene expressed exclusively in meiotic male germ cells

Looman C, Mark C, Abrink M, Hellman L


Spermatogenesis takes place in the seminiferous tubule in the testes and culminates in the production of spermatozoa (male gametes). Here we report the identification of a novel mouse zinc-finger gene, MZF6D, which is selectively expressed in meiotic spermatocytes. The MZF6D protein contains an N-terminally located repressor domain, a KRAB domain, followed by at least seven successive Kruppel zinc-finger motifs. The KRAB domain of MZF6D, which consists of a KRAB A box and the newly identified KRAB C box, has previously been shown to interact with TIF1beta, which is the common corepressor of all KRAB zinc-finger proteins. Northern blot analysis shows that the expression of MZF6D is restricted to testes. This was confirmed by RT-PCR analysis of a panel of mouse tissues. In situ hybridization of sections from adult mouse testes localizes the expression to meiotic spermatocytes, suggesting a specific role for MZF6D in the regulation of spermatogenesis

Published in

DNA and Cell Biology
2003, Volume: 22, number: 8, pages: 489-496

    SLU Authors

    • Åbrink, Magnus

      • Department of Molecular Biosciences, Swedish University of Agricultural Sciences

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