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Research article - Peer-reviewed, 2008

Verrucine F, a quinazoline from Penicillium verrucosum

Leong SI, Schnurer J, Broberg A

Abstract

Verrucine F (3), a quinazoline similar to verrucines A (1) and B (2), contains one anthranilic acid residue, one L-glutamine residue, and one alpha,beta-unsaturated phenylalanine residue, as determined by NMR, MS, and chemical methods. Compounds I and 3, but not 2, were produced by Penicillium verrucosum J255 and eight additional P. verrucosum strains. Verrucines were typically more concentrated in the inner (older) parts of the colony, and 3 peaked 4-8 days after 1, but at 10-fold lower concentrations (similar to 200 mu g/g). Verrucine F (3) formed spontaneously from 1 in buffered water solutions. probably by oxidation at C-1 followed by water elimination

Published in

Journal of Natural Products
2008, Volume: 71, number: 8, pages: 1455-1457
Publisher: AMER CHEMICAL SOC