Skip to main content
Research article - Peer-reviewed, 2008

Wirkung von Pimobendan oder Benazeprilhydrochlorid auf die Überlebenzeit von Hunden mit kongestiver Herzinsuffizienz durch natürlich auftretende myxomatöse Mitralklappenkrankung: Die QUEST-Studie

Haggstrom, J.; Boswood, A.; O'Grady, M.; Jons, O.; Smith, S.; Swift, S.; Borgarelli, M.; Gavaghan, B.; Kresken, J.-G.; Patteson, M.; Ablad, B.; Bussadori, C. M.; Giaus, T.; Kovacevic, A.; Rapp, M.; Santilli, R. A.; Tidholm, A.; Eriksson, A.; Belanger, M. C.; Deinert, M.;
Show more authors


Effect of Pimobendan or Benazepril Hydrochloride on survival times in dogs with congestive heart failure caused by naturally occuring myxomatous mitral valve disease: the QUEST studyBackground: Myxomatous mitral valve disease (MMVD) continues to be an important cause of morbidity and mortality in geriatric dogs despite conventional therapy.Hypothesis: Pimobendan in addition to conventional therapy will extend time to sudden cardiac death, euthanasia for cardiac reasons, or treatment failure when compared with conventional therapy plus benazepril in dogs with congestive heart failure (CHF) attributable to MMVD.Animals: 260 client-owned dogs in CHF caused by MMVD were recruited from 28 centers in Europe, Canada, and Australia.Methods: A prospective single-blinded study with dogs randomized to PO receive pimobendan (0.4-0.6 mg/kg/d) or benazepril hydrochloride (0.25-1.0 mg/kg/d). The primary endpoint was a composite of cardiac death, euthanized for heart failure, or treatment failure.Results: Eight dogs were excluded from analysis. 124 dogs were randomized to pimobendan and 128 to benazepril. 190 dogs reached the primary endpoint; the median time was 188 days (267 days for pimobendan, 140 days for benazepril, hazard ratio = 0.688, 95% confidence limits [CL] = 0.516-0.916, P = 0099). The benefit of pimobendan persisted after adjusting for all baseline variables. A longer time to reach the endpoint was also associated with being a Cavalier King Charles Spaniel, requiring a lower furosemide dose, and having a higher creatinine concentration. Increases in several indicators of cardiac enlargement (left atrial to aortic root ratio, vertebral heart scale, and percentage increase in left ventricular internal diameter in systole) were associated with a shorter time to endpoint, as was a worse tolerance for exercise.Conclusions and Clinical Importance: Pimobendan plus conventional therapy prolongs time to sudden death, euthanasia for cardiac reasons, or treatment failure in dogs with CHF caused by MMVD compared with benazepril plus conventional therapy.


Canine; Mitral regurgitation; Mortality; Therapy

Published in

2008, volume: 53, number: 12, pages: 745-762

Authors' information

Swedish University of Agricultural Sciences, Department of Clinical Sciences
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
DiFruscia, R.
University of Montreal
Show more authors

UKÄ Subject classification

Veterinary Science
Animal and Dairy Science

URI (permanent link to this page)