Phylogeny, classification and evolutionary insights into pestiviruses

Abstract

The genus Pestivirus comprises four established species: Bovine viral diarrhoea viruses 1 (BVDV-1) and 2 (BVDV-2), Border disease virus (BDV), and Classical swine fever virus (CSFV); and a tentative species, Pestivirus of giraffe. Additional pestiviruses have been identified and suggested for recognition as novel subgroups/species. To achieve a reliable phylogeny as the basis for classification of pestiviruses, a molecular dataset of 56 pestiviruses and 2089 characters, comprising the 5'UTR, complete N(pro) and E2 gene regions was analysed by Maximum likelihood and Bayesian approach. An identical, robust tree topology was inferred, where seven well-supported monophyletic clades and two highly divergent lineages were identified. Dating most recent common ancestor was estimated for major pestivirus lineages and their evolutionary histories were revealed. Accordingly, a new proposal is presented for the classification of pestiviruses into nine species: BVDV-1, BVDV-2, BVDV-3 (atypical bovine pestiviruses), Pestivirus of giraffe, CSFV, BDV, Tunisian sheep Virus (TSV; previously termed "Tunisian isolates"), Antelope and Bungowannah. (c) 2008 Elsevier Inc. All rights reserved.

Keywords

Bayesian approach; BDV; BVDV; Classification; CSFV; Evolution; Maximum likelihood; Pestivirus; Phylogeny

Published in

Virology
2009, volume: 385, number: 2, pages: 351-357

SLU Authors

• Liu, Lihong

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Xia, Hongyan

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Belak, Sandor

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Veterinary Science
Animal and Dairy Science

Publication identifier

• DOI: https://doi.org/10.1016/j.virol.2008.12.004

Permanent link to this page (URI)

https://res.slu.se/id/publ/20420