Abstract

Computational modeling was applied to investigate how cortical neu-rodynamics may depend on network connectivity. In particular, we study ef-fects of pruning of cortical networks, which may be related to the onset of dif-ferent mental disorders. In addition, we study changes in EEG pattern of de-pressed patients, following ECT (electroconvulsive therapy). The aim is to gain a better understanding of the neural mechanisms responsible for these changes, which include phase shifts in the EEG dynamics. This understanding is in-tended to provide clinical guidance, predicting ECT dose and response in de-pressed patients. Finally, we discuss the relevance of these results to clinical and experimental neuroscience and speculate on a link between neural instabil-ity and mental disorders

Keywords

Neurodynamics; network connectivity; EEG; ECT; pruning; mental disorder; computational models

Published in

Title: Advances in Cognitive Neurodynamics
ISBN: 9781402083860
Publisher: Springer

Conference

International Conference on Cognitive Neurodynamics

SLU Authors

• Liljenström, Hans

  • Department of Energy and Technology, Swedish University of Agricultural Sciences
    

Permanent link to this page (URI)

https://res.slu.se/id/publ/24099