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Research article2004Peer reviewed

C-reactive protein in the differentiation of pyometra from cystic endometrial hyperplasia/mucometra in dogs

Fransson BA, Karlstam E, Bergstrom A, Lagerstedt AS, Park JS, Evans MA, Ragle CA


Hematological parameters, plasma C-reactive protein (CRP), and tumor necrosis factor a were analyzed in 64 dogs with a presumptive diagnosis of pyometra. Final diagnosis (i.e., pyometra or cystic endometrial hyperplasia [CEH]) was determined by histopathology. As a single test, the percentage of band neutrophils had the highest sensitivity in the prediction of pyometra ( sensitivity, 94%). The combination of percentage of bands and CRP had the highest sensitivity (97.7%; specificity, 75%) in predicting the presence of pyometra. The most common clinical signs noted in the study were vaginal discharge, polyuria, polydipsia, lethargy, and gastrointestinal signs. A combination of three or more of these clinical signs was significantly associated with pyometra

Published in

Journal Of The American Animal Hospital Association
2004, Volume: 40, number: 5, pages: 391-399 Publisher: AMER ANIMAL HOSPITAL ASSOC