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Research article - Peer-reviewed, 2004

C-reactive protein in the differentiation of pyometra from cystic endometrial hyperplasia/mucometra in dogs

Fransson BA, Karlstam E, Bergstrom A, Lagerstedt AS, Park JS, Evans MA, Ragle CA


Hematological parameters, plasma C-reactive protein (CRP), and tumor necrosis factor a were analyzed in 64 dogs with a presumptive diagnosis of pyometra. Final diagnosis (i.e., pyometra or cystic endometrial hyperplasia [CEH]) was determined by histopathology. As a single test, the percentage of band neutrophils had the highest sensitivity in the prediction of pyometra ( sensitivity, 94%). The combination of percentage of bands and CRP had the highest sensitivity (97.7%; specificity, 75%) in predicting the presence of pyometra. The most common clinical signs noted in the study were vaginal discharge, polyuria, polydipsia, lethargy, and gastrointestinal signs. A combination of three or more of these clinical signs was significantly associated with pyometra

Published in

Journal Of The American Animal Hospital Association
2004, volume: 40, number: 5, pages: 391-399

Authors' information

Swedish University of Agricultural Sciences, Universitetsdjursjukhuset
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Evans, MA
Park, JS
Ragle, CA
Fransson, Boel
Karlstam, Erika

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science

Publication Identifiers


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