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Research article - Peer-reviewed, 2009

Multiple Origins of Foot-and-Mouth Disease Virus Serotype Asia 1 Outbreaks, 2003-2007

Valarcher, Jean-Francois; Knowles, Nick J.; Zakharov, Valery; Scherbakov, Alexey; Zhang, Zhidong; Shang, You-Jun; Liu, Zai-Xin; Liu, Xiang-Tao; Sanyal, Aniket; Hemadri, Divakar; Tosh, Chakradhar; Rasool, Thaha J.; Pattnaik, Bramhadev; Schumann, Kate R.; Beckham, Tammy R.; Linchongsubongkoch, Wilai; Ferris, Nigel P.; Roeder, Peter L.; Paton, David J.


We investigated the molecular epidemiology of foot- and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea. Phylogenetic analysis of complete virus capsid protein 1 (VP1) gene sequences demonstrated that the FMDV isolates responsible for these outbreaks belonged to 6 groups within the Asia 1 serotype. Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago. Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.

Published in

Emerging Infectious Disease
2009, volume: 15, number: 7, pages: 1046-1051

Authors' information

The Pirbright Institute
Knowles, Nick J.
Zakharov, Valery
Scherbakov, Alexey
Zhang, Zhidong
Shang, You-Jun
Liu, Zai-xin
Liu, Xiang-Tao
Lanzhou Veterinary Research Institute
Sanyal, Aniket
Hemadri, Divakar
Tosh, Chakradhar
Rasool, Taha J.
Pattnaik, Bramhadev
Schumann, Kate
Beckham, Tammy R.
Linchongsubongkoch, Wilai
Ferris, Nigel P.
Roeder, Peter L.
Paton, David J.

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science

Publication Identifiers


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