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Research article2009Peer reviewed

An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency

Rengman, Sofia; Fedkiv, Olexandr; Botermans, Jos; Svendsen, Jorgen; Westrom, Bjorn; Pierzynowski, Stefan

Abstract

Background & aims: Young individuals with exocrine pancreatic insufficiency (EPI) show growth reduction that can be reversed by dietary pancreatic enzyme supplementation. Here we investigated whether feeding an elemental diet Could replace the growth-promoting effect of enzyme supplementation in EPI pigs.Methods: Weaned pigs with intact pancreas (control) or pancreatic duct-ligated (EPI pigs) were given a commercial pig feed, a fat-enriched diet, or an elemental diet, intragastrically and intravenously, with or without porcine pancreatin (Creon (R)) supplementation for 1 week.Results: Control pigs, irrespective of receiving pig feed or an elemental diet, increased their body weight by 13.4-20.1%, while EPI pigs showed negligible weight gain. Giving a fat-enriched diet did not improve growth of the EPI pigs. However, if the EPI pigs were supplemented with pancreatin in combination with fat-enriched feed or the elemental diet, i.v., their body weight increased by 16.6% and 8.5%, respectively.Conclusion: Control pigs maintained normal growth, independently of the diet being given in polymeric or elemental form, while EPI pigs showed impaired growth when receiving the same diets without enzyme supplementation. Pancreatic juice and enzyme preparations, in addition to their digestive properties, also appear to affect nutrient assimilation and anabolism in young individuals. (C) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Keywords

Pancreatic enzyme preparation; Pancreatic duct ligation; Elemental diet; Polymeric diet

Published in

Clinical Nutrition
2009, volume: 28, number: 3, pages: 325-330

SLU Authors

  • Botermans, Jos

    • Department of Agricultural Biosystems and Technology, Swedish University of Agricultural Sciences

UKÄ Subject classification

Veterinary Science
Animal and Dairy Science

Publication identifier

  • DOI: https://doi.org/10.1016/j.clnu.2009.02.010

Permanent link to this page (URI)

https://res.slu.se/id/publ/26736