Research article - Peer-reviewed, 2010
Bone Morphogenetic Protein-2 Delivered by Hyaluronan-Based hydrogel Induces Massive Bone Formation and Healing of Cranial Defects in Minipigs
Docherty-Skogh, Ann-Charlott; Jensen Waern, Marianne; Bergman, Kristoffer; Ekman, Stina; Hultenby, Kjell; Ossipov, Dimitri; Hilborn, Jöns; Bowden, Tim; Engstrand, ThomasAbstract
Reconsruction of large craniofacial bone defects is a challenge using bone transplants of alloplastic materials. The use of bone morphogenetic protein (BMP)-2 together with a suitable carrier is an attractive option that may facilitate new bone formation. The authors have developed a hydrogel that is formed in situ by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives mixed with hydroxyapatite nonparticles in the precence of BMP-2Published in
Plastic and Reconstructive Surgery2010, volume: 125, number: 5, pages: 1383-1392
Publisher: Plastic and Reconstructive Surgery; prs@plasticsurgery.org
Authors' information
Docherty-Skogh, Ann-Charlott
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Bergman, Kristoffer
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Hultenby, Kjell
Ossipov, Dimitri
Hilborn, Jöns
Bowden, Tim
Engstrand, Thomas
UKÄ Subject classification
Animal and Dairy Science
Veterinary Science
Publication Identifiers
DOI: https://doi.org/10.1097/PRS.0b013e3181d629dc
URI (permanent link to this page)
https://res.slu.se/id/publ/29372