Jensen Waern, Marianne
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Research article2010Peer reviewed
Bone Morphogenetic Protein-2 Delivered by Hyaluronan-Based hydrogel Induces Massive Bone Formation and Healing of Cranial Defects in Minipigs
Docherty-Skogh, Ann-Charlott; Jensen Waern, Marianne; Bergman, Kristoffer; Ekman, Stina; Hultenby, Kjell; Ossipov, Dimitri; Hilborn, Jöns; Bowden, Tim; Engstrand, Thomas
Abstract
Reconsruction of large craniofacial bone defects is a challenge using bone transplants of alloplastic materials. The use of bone morphogenetic protein (BMP)-2 together with a suitable carrier is an attractive option that may facilitate new bone formation. The authors have developed a hydrogel that is formed in situ by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives mixed with hydroxyapatite nonparticles in the precence of BMP-2
Published in
Plastic and Reconstructive Surgery
2010, Volume: 125, number: 5, pages: 1383-1392
Publisher: Plastic and Reconstructive Surgery; prs@plasticsurgery.org
Ekman, Stina
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
SLU Authors
UKÄ Subject classification
Animal and Dairy Science
Veterinary Science
Publication identifier
DOI: https://doi.org/10.1097/PRS.0b013e3181d629dc
Permanent link to this page (URI)
https://res.slu.se/id/publ/29372