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Research article - Peer-reviewed, 2010

Bone Morphogenetic Protein-2 Delivered by Hyaluronan-Based hydrogel Induces Massive Bone Formation and Healing of Cranial Defects in Minipigs

Docherty-Skogh, Ann-Charlott; Jensen Waern, Marianne; Bergman, Kristoffer; Ekman, Stina; Hultenby, Kjell; Ossipov, Dimitri; Hilborn, Jöns; Bowden, Tim; Engstrand, Thomas


Reconsruction of large craniofacial bone defects is a challenge using bone transplants of alloplastic materials. The use of bone morphogenetic protein (BMP)-2 together with a suitable carrier is an attractive option that may facilitate new bone formation. The authors have developed a hydrogel that is formed in situ by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives mixed with hydroxyapatite nonparticles in the precence of BMP-2

Published in

Plastic and Reconstructive Surgery
2010, volume: 125, number: 5, pages: 1383-1392
Publisher: Plastic and Reconstructive Surgery;

Authors' information

Docherty-Skogh, Ann-Charlott
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Bergman, Kristoffer
Hultenby, Kjell
Ossipov, Dimitri
Hilborn, Jöns
Bowden, Tim
Engstrand, Thomas

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science

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