Research article - Peer-reviewed, 2011
Pharmacokinetics of meloxicam in adult goats and its analgesic effect in disbudded kids
Ingvast Larsson Carina, Högberg Madeleine, Mengistu Urge, Olsén Lena, Bondesson Ulf, Olsson KerstinAbstract
The pharmacokinetics and analgesic effect of the nonsteroidal anti-inflammatory drug meloxicam (0.5 mg⁄ kg) in goats were investigated. In a randomized, cross-over design the pharmacokinetic parameters were investigated in adult goats (n = 8) after single intravenous and oral administration. The analgesic effect was evaluated in kids using a randomized, placebo controlled and blinded protocol. Kids received meloxicam (n = 6) once daily and their siblings (n = 5) got isotonic NaCl intramuscularly while still anaesthetized after cautery disbudding and injections were repeated on three consecutive days. In the adult goats after intravenous administration the terminal half-life was 10.9 ± 1.7 h, steady-state volume of distribution was 0.245 ± 0.06 L ⁄ kg, and total body clearance was 17.9 ± 4.3 mL⁄ h⁄ kg. After oral administration bioavailability was 79 ± 19%, Cmax was 736 ± 184 ng ⁄ mL, Tmax was 15 ± 5 h, although the terminal half-life was similar to the intravenous value, 11.8 ± 1.7 h. Signs of pain using a visual analogue scale were smaller in kids treated with meloxicam compared with kids treated with placebo on the first day after disbudding, but subsequently no difference in pain was noticeable. Plasma cortisol and glucose concentrations did not differ between the two groupsKeywords
Cautery disbudding; Goat; Meloxicam; Pain induced stress; PharmacokineticsPublished in
Journal of Veterinary Pharmacology and Therapeutics2011, volume: 34, number: 1, pages: 64-69
Authors' information
Ingvast Larsson, Carina
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Högberg, Madeleine
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Mengistu, Urge
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Bondesson, Ulf
Olsson, Kerstin
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
UKÄ Subject classification
Animal and Dairy Science
Veterinary Science
Publication Identifiers
DOI: https://doi.org/10.1111/j.1365-2885.2010.01195.x
URI (permanent link to this page)
https://res.slu.se/id/publ/30151