Abstract

A multi-type branching process with varying environment was used to construct a pharmacokinetic/pharmacodynamic (PK/PD) model that captures the postantibiotic effect (PAE) seen in bacterial populations after exposure of antibiotics. This phenomenon of continued inhibition of bacterial growth even after removal of the antibiotic from the growth medium is of high relevance in the context of optimizing dosing regimens. The clinical implication of long PAEs lies in the interesting possibility of increasing the intervals between drug administrations.The model structure is generalizable to most types of antibiotics and is useful both as a theoretical framework for understanding the time properties of PAE and to explore optimal antibiotic dosing regimens. Data from an in vitro study with Escherichia coli exposed to different dosing regimens of cefotaxime were used to evaluate the model. (C) 2008 Elsevier Ltd. All rights reserved.

Keywords

Antibiotic resistance; Mathematical model; Penicillin binding proteins

Published in

Journal of Theoretical Biology
2009, Volume: 256, number: 1, pages: 58-64

UKÄ Subject classification

Biochemistry and Molecular Biology


Publication identifier

DOI: https://doi.org/10.1016/j.jtbi.2008.09.023

Permanent link to this page (URI)

https://res.slu.se/id/publ/31154