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Research article - Peer-reviewed, 2010

Detergent-like interaction of Congo red with the amyloid beta peptide

Lendel, Christofer; Bolognesi, Benedetta; Wahlstrom, Anna; Dobson, Christopher M.; Graslund, Astrid


Accumulating evidence links prefibrillar oligomeric species of the amyloid beta peptide (A beta) to cellular toxicity in Alzheimer's disease, potentially via disruption of biological membranes. Congo red (CR) affects protein aggregation. It is known to self-associate into micelle-like assemblies but still reduces the toxicity of A beta aggregates in cell cultures and model organisms. We show here that CR interacts with A beta(1-40) in a manner similar to that of anionic detergents. Although CR promotes beta sheet formation and peptide aggregation, it may also solubilize toxic protein species, making them less harmful to critical cellular components and thereby reducing amyloid toxicity.

Published in

2010, volume: 49, number: 7, pages: 1358-1360

Authors' information

Lendel, Christofer
University of Cambridge
Bolognesi, Benedetta
Dobson, Christopher M.
Gräslund, Astrid
Stockholm University
Wahlström, Anna

UKÄ Subject classification

Food Science

Publication Identifiers


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