Skip to main content
Research article - Peer-reviewed, 2011

The naïve airway hyperresponsiveness of the A/J mouse is Kit-mediated

Cozzi Emily, Ackerman Kate G, Lundequist Anders, Drazen Jeffrey M, Boyce Joshua A, Beier David R


There is a wide variation among humans and mice in airway hyperresponsiveness (AHR) in the absence of allergen sensitization, i.e., naïve AHR. Because mast cell (MC) activation is thought to mediate AHR in atopic asthmatic subjects, we asked whether MCs mediate naïve AHR in A/J mice. We generated an A/J congenic strain lacking c-Kit by introgression of the Wv mutation, which resulted in the elimination of MCs and the abrogation of naïve AHR. Imatinib, which disrupts Kit signaling, also abrogated AHR in A/J mice. Remarkably, introduction of the Vga9 Mitf mutation into the A/J background resulted in the ablation of MCs but did not ameliorate AHR. These results indicate that c-Kit is required for development of AHR in an MC-independent fashion

Published in

Proceedings of the National Academy of Sciences
2011, volume: August 2, 2011 vol. 108, number: no. 31, pages: 12787-12792

Authors' information

Cozzi, Emily
Ackerman, Kate G
Lundequist, Anders
Harvard Medical School
Drazen, Jeffrey M
Boyce, Joshua A
Beier, David R

UKÄ Subject classification

Respiratory Medicine and Allergy

Publication Identifiers


URI (permanent link to this page)