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Research article - Peer-reviewed, 2009

Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse

Nyman Görel, Marntell Stina, Edner Anna, Funkquist Pia, Morgan Karin, Hedenstierna Göran

Abstract

Background Sedation with α2-agonists in the horse is reported to be accompanied by impairment of arterial oxygenation. The present study was undertaken to investigate pulmonary gas exchange using the Multiple Inert Gas Elimination Technique (MIGET), during sedation with the α2-agonist detomidine alone and in combination with the opioid butorphanol. Methods Seven Standardbred trotter horses aged 3-7 years and weighing 380-520 kg, were studied. The protocol consisted of three consecutive measurements; in the unsedated horse, after intravenous administration of detomidine (0.02 mg/kg) and after subsequent butorphanol administration (0.025 mg/kg). Pulmonary function and haemodynamic effects were investigated. The distribution of ventilation-perfusion ratios (VA/Q) was estimated with MIGET. Results During detomidine sedation, arterial oxygen tension (PaO2) decreased (12.8‒0.7 to 10.8‒1.2 kPa) and arterial carbon dioxide tension (PaCO2) increased (5.9‒0.3 to 6.1‒0.2 kPa) compared to measurements in the unsedated horse. Mismatch between ventilation and perfusion in the lungs was evident, but no increase in intrapulmonary shunt could be detected. Respiratory rate and minute ventilation did not change. Heart rate and cardiac output decreased, while pulmonary and systemic blood pressure and vascular resistance increased. Addition of butorphanol resulted in a significant decrease in ventilation and increase in PaCO2. Alveolar-arterial oxygen content difference P(A-a)O2 remained impaired after butorphanol administration, the VA/Q distribution improved as the decreased ventilation andpersistent low blood flow was well matched. Also after subsequent butorphanol no increase in intrapulmonary shunt was evident. Conclusions The results of the present study suggest that both pulmonary and cardiovascular factors contribute to the impaired pulmonary gas exchange during detomidine and butorphanol sedation in the horse

Published in

Acta Veterinaria Scandinavica
2009, Volume: 51, pages: 1-9

      SLU Authors

        • Morgan, Karin

          • Department of Equine Studies, Swedish University of Agricultural Sciences

        UKÄ Subject classification

        Veterinary Science
        Animal and Dairy Science

        Publication identifier

        DOI: https://doi.org/10.1186/1751-0147-51-22

        Permanent link to this page (URI)

        https://res.slu.se/id/publ/35885